Department of Health Sciences, University of L'Aquila, Via Vetoio, Italy.
Int Braz J Urol. 2011 Sep-Oct;37(5):617-22. doi: 10.1590/s1677-55382011000500008.
Emerging insights underline a link among chronic inflammation and endothelial activation with benign prostatic hyperplasia (BPH) and prostate cancer (PCa). We aim to investigate whether specific plasma markers of inflammation and endothelial activation allow to discriminate BPH and PCa.
Fifteen patients affected by BPH, 15 by PCa and 15 controls, were enrolled. Interleukin-6 (IL-6), CD40 ligand (CD40L), endothelial-selectin (E-selectin), platelet-selectin (P-selectin), vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) were measured.
In systemic blood samples, IL-6 has been found increased in patients affected by BPH (4.25 ± 0. pg/mL) and PCa (5.08 ± 0.24) respect to controls (2.62 ± 0.34; p < 0.05). CD40L was higher in BPH (4.25 ± 0.65 ng/mL; p < 0.05) than in control (2.31 ± 0.20) and PCa group (2.60 ± 0.56). E-selectin, P-selectin and VCAM-1 did not show any significant difference. Higher levels of ICAM-1 were detected in patients with PCa (573.04 ± 52.23) and BPH (564.40 ± 74.67) than in the controls (215.30 ± 11.53 ng/mL; p < 0.05). In local blood samples, IL-6 has been found significantly increased in PCa in comparison with patients with BPH; there was no difference in CD40L, E-selectin, P-selectin, VCAM-1 ed ICAM-1.
Changes in inflammation and endothelial activation markers may be not considered to be of value in discriminating BPH and PCa.
新出现的观点强调了慢性炎症与内皮细胞激活与良性前列腺增生（BPH）和前列腺癌（PCa）之间的联系。我们旨在研究炎症和内皮细胞激活的特定血浆标志物是否可以区分 BPH 和 PCa。
共纳入 15 例 BPH 患者、15 例 PCa 患者和 15 例对照者。测定白细胞介素 6（IL-6）、CD40 配体（CD40L）、内皮选择素（E-选择素）、血小板选择素（P-选择素）、血管细胞黏附分子-1（VCAM-1）和细胞间黏附分子-1（ICAM-1）。
在系统性血液样本中，BPH（4.25±0.65 pg/ml）和 PCa（5.08±0.24）患者的 IL-6 高于对照组（2.62±0.34；p<0.05）。BPH 患者的 CD40L（4.25±0.65ng/ml；p<0.05）高于对照组（2.31±0.20）和 PCa 组（2.60±0.56）。E-选择素、P-选择素和 VCAM-1 无显著差异。PCa（573.04±52.23）和 BPH（564.40±74.67）患者的 ICAM-1 水平明显高于对照组（215.30±11.53ng/ml；p<0.05）。局部血液样本中，PCa 患者的 IL-6 明显高于 BPH 患者；CD40L、E-选择素、P-选择素、VCAM-1 和 ICAM-1 无差异。
炎症和内皮细胞激活标志物的变化可能不能用于区分 BPH 和 PCa。
