Cao De-Hong, Liu Liang-Ren, Li Li, Fang Yu, Tang Ping, Li Tao, Wang Jia, Wei Qiang
Department of Urology, Institute of Urology, West China Hospital, Sichuan University Chengdu 61000, China.
Laboratory of Pathology, West China Hospital, Sichuan University Chengdu 61000, China.
Int J Clin Exp Pathol. 2017 Nov 1;10(11):10863-10872. eCollection 2017.
This paper aims to investigate the pathological characteristics of CD40/CD40L and NF-κB proteins related to inflammation in benign prostatic hyperplasia (BPH) tissue, as well as the outcomes of inflammation. A total of 120 BPH samples were obtained, and clinical data were gathered. The prevalence of BPH-associated inflammation was 91.7%, while inflammation infiltrates were more likely to be mild, multifocal, and stromal. Patients were divided into grades 0, 1, 2, and 3 according to the grade of inflammation. Serum prostate specific antigen (PSA) levels, prostate volumes, and International Prostate Symptom Score (IPSS) were higher in grade 1, 2, and 3 patients (increasing with the grade) than those in grade 0 patients. In addition, the present study demonstrated that CD40 and CD40L were mainly expressed in prostate epithelial cell membranes and some areas of the cytoplasm, whereas NF-κB proteins were mainly expressed in the cytoplasm and nuclei of glandular epithelial cells and prostatic stromal cells but less likely expressed in normal tissues. In the BPH group associated with inflammation, the positive expression rates of these proteins obviously gradually increased along with an increase in the degree of inflammation. BPH-associated with inflammation is a common condition that is associated with higher prostatic volumes, PSA levels, and IPSS compared with BPH alone. Moreover, CD40/CD40L and NF-κB expressions in BPH tissues were associated with the degree of inflammation and may play a role in BPH.
本文旨在研究良性前列腺增生（BPH）组织中与炎症相关的CD40/CD40L和NF-κB蛋白的病理特征，以及炎症的结果。共获取120份BPH样本，并收集临床数据。BPH相关炎症的患病率为91.7%，而炎症浸润多为轻度、多灶性且位于间质。根据炎症分级将患者分为0、1、2和3级。1、2和3级患者的血清前列腺特异性抗原（PSA）水平、前列腺体积和国际前列腺症状评分（IPSS）高于0级患者（随分级增加）。此外，本研究表明，CD40和CD40L主要表达于前列腺上皮细胞膜和部分细胞质区域，而NF-κB蛋白主要表达于腺上皮细胞和前列腺基质细胞的细胞质和细胞核中，在正常组织中表达较少。在伴有炎症的BPH组中，这些蛋白的阳性表达率明显随炎症程度的增加而逐渐升高。与单纯BPH相比，伴有炎症的BPH是一种常见情况，与更高的前列腺体积、PSA水平和IPSS相关。此外，BPH组织中CD40/CD40L和NF-κB的表达与炎症程度相关，可能在BPH中起作用。
