Department of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria 3084, Australia.
Cancer Lett. 2012 Apr 1;317(1):65-71. doi: 10.1016/j.canlet.2011.11.014. Epub 2011 Nov 15.
The p21-activated kinase 1 (PAK1) plays important roles in cell growth, motility, and transformation. The aims of this study were to delineate the signalling mechanisms downstream of PAK1, and to investigate the importance of PAK1 for colorectal cancer (CRC) growth and metastasis in vivo. PAK1 knockdown in human CRC cell lines inhibited β-catenin expression, β-catenin/TCF4 transcriptional activity, and the expression of c-Myc. In mouse models PAK1 knockdown suppressed the growth and metastasis of human CRC cells by decreasing proliferation and increasing apoptosis. Our findings demonstrate for the first time the crucial role of PAK1 in CRC progression in vivo.
p21 激活激酶 1（PAK1）在细胞生长、运动和转化中发挥重要作用。本研究旨在描绘 PAK1 下游的信号机制，并研究 PAK1 对结直肠癌（CRC）体内生长和转移的重要性。在人 CRC 细胞系中敲低 PAK1 抑制β-连环蛋白表达、β-连环蛋白/TCF4 转录活性和 c-Myc 的表达。在小鼠模型中，PAK1 敲低通过减少增殖和增加细胞凋亡来抑制人 CRC 细胞的生长和转移。我们的研究结果首次证明了 PAK1 在体内 CRC 进展中的关键作用。
