（±）-13-羟基-3,11-二氮甾体的合成与表征。
Synthesis and characterization of (±)-13-hydroxy-3,11-diaza steroids.
机构信息
Institut des Sciences Moléculaires de Marseille, UMR 6263 CNRS, Université d'Aix Marseille III, Faculté des Sciences et Techniques de Saint Jérôme, Marseille, France.
出版信息
Steroids. 2012 Jan;77(1-2):157-67. doi: 10.1016/j.steroids.2011.11.003. Epub 2011 Nov 11.
An efficient strategy for introducing a nitrogen atom in positions 3 and 11 of the steroidal skeleton, which are key positions for biological purposes, is described. This procedure involves an intramolecular Diels-Alder cycloaddition of o-quinodimethanes which are generated from a 3-azabicyclo[4.2.0]octa-1,3,5-trien-7-one. The characteristic (1)H and (13)C NMR spectroscopic features of the synthesized compounds are reported.
描述了一种在甾体骨架的 3 位和 11 位引入氮原子的有效策略，这两个位置对于生物目的至关重要。该方法涉及从 3-氮杂双环[4.2.0]辛-1,3,5-三烯-7-酮生成的邻醌二亚甲基的分子内 Diels-Alder 环加成反应。报道了合成化合物的特征（1）H 和（13）C NMR 光谱特征。
Zotero 插件