考替司他丁的全合成。
Formal synthesis of cortistatins.
机构信息
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
出版信息
J Org Chem. 2011 Apr 15;76(8):2479-87. doi: 10.1021/jo102202t. Epub 2011 Mar 10.
PMID:21391624
Abstract
A unified strategy toward the asymmetric facile construction of the [6.7.6.5]oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA), oxidative dearomatization, and an oxy-Michael addition reaction.
摘要
报道了一种不对称简便构建考替他汀类化合物[6.7.6.5]氧杂五环骨架的统一策略，其特征在于分子内 Diels-Alder（IMDA）反应、氧化去芳构化和氧迈克尔加成反应。
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