Department of Pathology, University of Pittsburgh Medical Center - Shadyside, Pittsburgh, PA, USA.
Pathol Res Pract. 2012 Jan 15;208(1):50-2. doi: 10.1016/j.prp.2011.10.003. Epub 2011 Nov 17.
Tumor-to-tumor metastasis is a very rare event. The recipient tumor may be benign or malignant. Renal cell carcinoma is the most common tumor recipient of metastasis while lung carcinoma is the most common donor tumor. We report a 57-year-old Caucasian male who presented with chest pain. On PET CT Scan, he was also found to have a large renal mass for which he underwent left nephrectomy. On histology of the renal mass, the tumor was a conventional renal cell carcinoma with areas of metastatic non-small cell lung carcinoma. The two components had a distinctive morphology which was confirmed on subsequent immunohistochemistry. The physiopathological mechanisms making clear cell renal cell carcinoma an avid recipient of a metastatic carcinoma have been speculated upon, but are still unknown.
肿瘤对肿瘤转移是一种非常罕见的现象。受体肿瘤可以是良性的，也可以是恶性的。肾细胞癌是最常见的转移受体肿瘤，而肺癌是最常见的供体肿瘤。我们报告了一名 57 岁的白人男性，他因胸痛就诊。在 PET CT 扫描中，还发现他有一个大的肾肿块，因此他接受了左肾切除术。在肾肿块的组织学检查中，肿瘤是一个常规的肾细胞癌，并有非小细胞肺癌的转移区域。这两个成分具有独特的形态，随后的免疫组织化学检查也证实了这一点。使透明细胞肾细胞癌成为转移性癌的热衷受体的病理生理机制已被推测出来，但仍不清楚。
