Sonnenberg A
Division of Gastroenterology, Veterans Administration Medical Center, Milwaukee, Wisc.
Digestion. 1990;46(1):10-8. doi: 10.1159/000200273.
A characteristic pattern in the occupational distribution of idiopathic inflammatory bowel disease (IBD) could help to focus research with regard to its etiology or reveal the nature of possible environmental risk factors. The present study analyses occupational mortality from Crohn's disease and ulcerative colitis in England and Wales during 8 consecutive years. Mortality of various occupations was expressed as proportional mortality ratio (PMR) or standardized mortality ratio (SMR). From 1979 to 1986, 321 men aged 16-74 years died from Crohn's disease, and 406 men died from ulcerative colitis. The respective number in women were 561 and 429. In men, there was a correlation between PMR and SMR among various occupations, with r = 0.80 and 0.65 for Crohn's disease and ulcerative colitis, respectively. A relatively low occurrence of male IBD was found in occupations associated with physical work, lower social status, and farming. By contrast, high mortality from IBD tended to be associated with physically less demanding work, sedentary occupations, and type of work which is done indoors.
特发性炎症性肠病（IBD）职业分布中的特征模式有助于聚焦其病因研究或揭示潜在环境风险因素的本质。本研究分析了英格兰和威尔士连续8年克罗恩病和溃疡性结肠炎的职业死亡率。各职业的死亡率以比例死亡率（PMR）或标准化死亡率（SMR）表示。1979年至1986年，16至74岁的男性中有321人死于克罗恩病，406人死于溃疡性结肠炎。女性的相应数字分别为561人和429人。在男性中，各职业的PMR和SMR之间存在相关性，克罗恩病和溃疡性结肠炎的r值分别为0.80和0.65。在与体力劳动、社会地位较低和务农相关的职业中，男性IBD的发病率相对较低。相比之下，IBD的高死亡率往往与体力要求较低的工作、久坐职业以及室内工作类型有关。
