Sonnenberg A
Dis Colon Rectum. 1986 Oct;29(10):624-9. doi: 10.1007/BF02560320.
As the etiology of inflammatory bowel disease remains unknown, studies of its time trends may provide clues to understanding the underlying mechanisms. This study examines mortality from Crohn's disease and ulcerative colitis in England and Wales and the U.S. during the period 1950 to 1983. Mortality from Crohn's disease and ulcerative colitis changed in both countries similarly. The death rates from Crohn's disease increased until 1970 to 1974 and decreased thereafter. The death rates from ulcerative colitis decreased throughout the observation period. Similar time trends occurred in men and women, and in the U.S. in whites and nonwhites. In the U.S., the death rates from both diseases were twofold higher in whites than nonwhites. The temporal changes suggest that mortality from inflammatory bowel disease is affected by exogenous factors and that these factors are different for Crohn's disease than for ulcerative colitis. These factors seem to have changed similarly in England and in the U.S.
由于炎症性肠病的病因仍不明确，对其时间趋势的研究可能为理解潜在机制提供线索。本研究调查了1950年至1983年期间英格兰、威尔士和美国克罗恩病和溃疡性结肠炎的死亡率。两国克罗恩病和溃疡性结肠炎的死亡率变化相似。克罗恩病的死亡率在1970年至1974年期间上升，此后下降。溃疡性结肠炎的死亡率在整个观察期内下降。男性和女性以及美国白人和非白人中都出现了类似的时间趋势。在美国，这两种疾病的白人死亡率比非白人高出两倍。时间变化表明，炎症性肠病的死亡率受外部因素影响，且这些因素在克罗恩病和溃疡性结肠炎中有所不同。这些因素在英国和美国的变化似乎相似。
