Noda A, Okumura I, Kato H, Ibuki E, Tamada M, Watanabe T
Third Department of Internal Medicine, Aichi Medical University, Japan.
Digestion. 1990;46(1):19-26. doi: 10.1159/000200274.
To examine pancreatic excretion of dimethadione (DMO), a weak organic acid, as well as of its precursor trimethadione (TMO), TMO was given orally to dogs with pancreatic fistulae at a dose of 10-160 mg/kg/day over a period of 14 days. Blood samples were taken once a day during the administration of TMO and for 7 days after discontinuation of the drug. On the 15th day, pancreatic juice was collected under stimulation by secretin (2 Crick-Haper-Raper units/kg/h). DMO concentration in plasma reached a maximal plateau around the 10th day after starting TMO administration, and depended directly on the dose of TMO. Pancreatic excretion of DMO at a steady state closely depended on both the dose of TMO and the DMO concentration in plasma. The pancreatic juice/plasma concentration ratio for DMO exceeded 1.0 at a steady rate and decreased with the increased flow rate. Pancreatic DMO clearance (DMO output/DMO concentration in plasma) increased, depending on the flow rate, the bicarbonate concentration, and pH of pancreatic juice. Pancreatic excretion of TMO was zero or extremely low.
为研究弱有机酸二甲双酮（DMO）及其前体三甲双酮（TMO）的胰腺排泄情况，对患有胰瘘的犬口服给予TMO，剂量为10 - 160mg/kg/天，持续14天。在给予TMO期间每天采集一次血样，并在停药后7天内每天采集。在第15天，通过促胰液素（2克里克 - 哈珀 - 拉珀单位/千克/小时）刺激收集胰液。血浆中DMO浓度在开始给予TMO后约第10天达到最大平台期，且直接取决于TMO的剂量。稳态下DMO的胰腺排泄密切依赖于TMO的剂量和血浆中DMO的浓度。DMO的胰液/血浆浓度比稳定超过1.0，并随流速增加而降低。胰腺DMO清除率（DMO输出量/血浆中DMO浓度）随胰液流速、碳酸氢盐浓度和pH值的变化而增加。TMO的胰腺排泄量为零或极低。
