Noda A, Hayakawa T, Mizuno R, Hamano H, Murase T, Shibata T
Gastroenterol Jpn. 1984 Apr;19(2):121-6. doi: 10.1007/BF02806934.
The excretion of dimethadione (DMO) in pure pancreatic juice and bile was studied in postoperative patients undergoing external drainage of pancreatic juice and in those who had undergone percutaneous transhepatic cholangiodrainage. During and after oral administration of trimethadione, which is the precursor of DMO, pancreatic DMO concentration closely paralleled plasma DMO concentration. Pancreatic juice/plasma concentration ratio for DMO exceeded 1.0. In a patient with a large pancreatic cyst communicating with the main pancreatic duct, pancreatic DMO concentration after single rapid injection of secretin inversely correlated with the flow rate, while its output depended directly on the rate. Biliary DMO output after secretin injection was closely dependent on the flow rate, but was extremely low. The present results are essentially compatible with the findings previously observed in dogs.
在接受胰液外引流的术后患者以及接受经皮经肝胆管引流的患者中，研究了二甲基乙二酮（DMO）在纯胰液和胆汁中的排泄情况。在口服DMO的前体三甲双酮期间及之后，胰液中DMO的浓度与血浆中DMO的浓度密切平行。DMO的胰液/血浆浓度比超过1.0。在一名有与主胰管相通的大胰腺囊肿的患者中，单次快速注射促胰液素后，胰腺DMO浓度与流速呈负相关，而其输出量直接取决于流速。注射促胰液素后的胆汁DMO输出量密切依赖于流速，但极低。目前的结果与先前在狗身上观察到的结果基本相符。
