Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Edinburgh, UK.
Neurosci Biobehav Rev. 2012 Feb;36(2):901-42. doi: 10.1016/j.neubiorev.2011.10.008. Epub 2011 Nov 11.
Recent years have seen a rapid increase in the investigation of autism spectrum disorders (ASD) through the use of functional magnetic resonance imaging (fMRI). We carried out a systematic review and ALE meta-analysis of fMRI studies of ASD. A disturbance to the function of social brain regions is among the most well replicated finding. Differences in social brain activation may relate to a lack of preference for social stimuli as opposed to a primary dysfunction of these regions. Increasing evidence points towards a lack of effective integration of distributed functional brain regions and disruptions in the subtle modulation of brain function in relation to changing task demands in ASD. Limitations of the literature to date include the use of small sample sizes and the restriction of investigation to primarily high functioning males with autism.
近年来，通过功能磁共振成像（fMRI）对自闭症谱系障碍（ASD）进行了大量研究。我们对 ASD 的 fMRI 研究进行了系统评价和 ALE 荟萃分析。研究发现，社交脑区功能障碍是最常见的一种现象。社交脑区激活的差异可能与对社交刺激缺乏偏好有关，而不是这些区域的主要功能障碍。越来越多的证据表明，在 ASD 中，分布式功能脑区的整合效果不佳，以及与任务需求变化相关的脑功能细微调节出现中断。目前文献的局限性包括样本量小，以及主要集中在高功能自闭症男性身上。
