Department of Chemistry and Centre for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Int J Pharm. 2012 Jan 17;422(1-2):254-63. doi: 10.1016/j.ijpharm.2011.11.007. Epub 2011 Nov 10.
A novel extrusion printing system was used to create drug delivery structures wherein dexamethasone-21-phosphate disodium salt (Dex21P) was encapsulated within a biodegradable polymer (PLGA) and water soluble poly(vinyl alcohol) (PVA) configurations. The ability to control the drug release profile through the spatial distribution of drug within the printed 3-dimensional structures is demonstrated. The fabricated configurations were characterised by optical microscopy and SEM to evaluate surface morphology. The results clearly demonstrate the successful encapsulation of dexamethasone within a laminated PLGA:PVA structure. The resulting drug release profiles from the structures show a two stage release profile with distinctly different release rates and minimal initial burst release observed. Dexamethasone release was monitored over a 4-month period. This approach clearly demonstrates that the extrusion printing technique provides a facile and versatile approach to fabrication of novel drug delivery platforms.
一种新颖的挤出打印系统被用于创建药物输送结构，其中地塞米松-21-磷酸二钠盐（Dex21P）被包封在可生物降解聚合物（PLGA）和水溶性聚乙烯醇（PVA）结构内。通过打印的 3 维结构内药物的空间分布来控制药物释放特性的能力得到了证明。通过光学显微镜和 SEM 对制造的结构进行了特征描述，以评估表面形态。结果清楚地表明，地塞米松成功地包封在层压的 PLGA：PVA 结构内。从结构中释放的药物显示出具有明显不同的释放速率的两阶段释放特性，并且观察到最小的初始突释。监测了地塞米松在 4 个月期间的释放情况。该方法清楚地表明，挤出打印技术为新型药物输送平台的制造提供了一种简单而通用的方法。
