Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL 33612, USA.
Cancer Causes Control. 2012 Feb;23(2):245-54. doi: 10.1007/s10552-011-9872-y. Epub 2011 Nov 19.
To investigate the association between cigarette smoking and basal and squamous cell carcinomas (BCC and SCC) of the skin, a clinic-based case-control study was conducted in Tampa, FL.
Patients with histologically confirmed BCC/SCC were recruited from a university dermatology clinic (n = 215 BCC, 165 SCC). Controls were comprised of individuals with no history of skin cancer who screened negative for skin cancer upon physical examination at the affiliated cancer screening or primary care clinics (n = 315). Information on smoking and other risk factors was obtained from self-administered questionnaires.
After adjustment for age, sex, and other skin cancer-risk factors, ever smoking was not associated with BCC (odds ratio (OR) = 1.26, 95% confidence interval (CI) = 0.83-1.92), but was statistically significantly associated with SCC (OR = 1.97, 95% CI = 1.19-3.26), with significant trends observed for SCC associated with increasing cigarettes per day (p = 0.01) and pack-years smoked (p = 0.01). Among men, smoking ≥20 pack-years was associated with non-significant increased risks of BCC (OR = 1.90, 95% CI = 0.88-4.12) and SCC (OR = 1.97, 95% CI = 0.84-4.66), whereas among women, no association was observed with BCC (OR = 0.98, 95% CI = 0.39-2.46) while a statistically significant three-fold risk was observed with SCC (OR = 3.00, 95% CI = 1.02-8.80).
Cigarette smoking is more strongly associated with SCC than BCC, particularly among women.
为了研究吸烟与基底细胞癌（BCC）和鳞状细胞癌（SCC）的相关性，在佛罗里达州坦帕市进行了一项基于诊所的病例对照研究。
从大学皮肤科诊所招募了组织学确诊为 BCC/SCC 的患者（BCC 患者 215 例，SCC 患者 165 例）。对照组由没有皮肤癌病史且在相关癌症筛查或初级保健诊所进行体检时筛查出无皮肤癌的个体组成（n=315）。通过自填问卷获取有关吸烟和其他危险因素的信息。
在调整年龄、性别和其他皮肤癌危险因素后，吸烟与 BCC 无关（比值比（OR）=1.26，95%置信区间（CI）=0.83-1.92），但与 SCC 呈统计学显著相关（OR=1.97，95%CI=1.19-3.26），并且与 SCC 相关的趋势随着每天吸烟量（p=0.01）和吸烟包年数（p=0.01）的增加而显著。在男性中，吸烟≥20 包年与 BCC（OR=1.90，95%CI=0.88-4.12）和 SCC（OR=1.97，95%CI=0.84-4.66）的非显著风险增加相关，而在女性中，与 BCC 无关（OR=0.98，95%CI=0.39-2.46），而 SCC 则呈现统计学上显著的三倍风险（OR=3.00，95%CI=1.02-8.80）。
吸烟与 SCC 的相关性强于 BCC，特别是在女性中。
