Morriston Hospital, Morriston, Swansea Wales.
Emerg Med J. 2011 Dec;28(12):1076-7. doi: 10.1136/emermed-2011-200891.
A short cut review was carried out to establish whether ketamine is a viable induction agent in trauma patients with potential brain injuries. 276 papers were found using the reported searches, of which 5 presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. It is concluded that there is no evidence to suggest harm with Ketamine use as induction agent for the patient with potential traumatic brain injury. The drug has major advantages in those patients with associated haemodynamic compromise and should potentially be regarded as the agent of choice.
一篇简短的综述回顾旨在确定氯胺酮是否可作为伴有潜在脑损伤的创伤患者的一种可行诱导剂。通过所报告的检索共发现 276 篇论文,其中 5 篇提供了最佳证据来回答临床问题。作者、日期和国家/地区、研究的患者群体、研究类型、相关结果、这些最佳论文的研究弱点都被制成表格。结论是,没有证据表明氯胺酮作为潜在创伤性脑损伤患者的诱导剂使用会造成伤害。该药物在伴有血流动力学不稳定的患者中有显著优势,因此应该被视为首选药物。