Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital and the Ohio State University, 700 Children's Drive, Columbus, OH 43205, USA.
J Anesth. 2012 Apr;26(2):250-3. doi: 10.1007/s00540-011-1269-2. Epub 2011 Nov 19.
Neuroleptic malignant syndrome (NMS) is a rare disorder which is clinically similar to malignant hyperthermia (MH). It is characterized by hyperthermia, autonomic instability, muscle rigidity, coma, rhabdomyolysis, and acidosis. Without immediate and appropriate therapy, mortality may result. NMS is associated with administration of antipsychotic medications, anti-emetic medications, and changes in the dosage of anti-parkinsonian drugs. As several similarities exist between NMS and MH, differentiating between them can be a challenge for the clinician. We report anesthetic care during magnetic resonance imaging of the brain of a 14-year-old female with bipolar and schizoaffective disorders and the recent onset of NMS.
神经阻滞剂恶性综合征（NMS）是一种罕见的疾病，其临床症状与恶性高热（MH）相似。其特征为高热、自主神经不稳定、肌肉僵硬、昏迷、横纹肌溶解和酸中毒。如果不及时进行适当的治疗，可能会导致死亡。NMS 与抗精神病药物、止吐药物的使用以及抗帕金森病药物剂量的改变有关。由于 NMS 和 MH 之间存在一些相似之处，因此对临床医生来说，区分两者具有一定的挑战性。我们报告了一例 14 岁女性双相情感障碍和精神分裂情感障碍患者，在近期出现 NMS 后，进行脑部磁共振成像检查时的麻醉护理。
