他汀类药物引起的肌肉并发症的流行情况和危险因素。
Prevalence and risk factors of muscle complications secondary to statins.
机构信息
Department of Neurosciences, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
出版信息
Muscle Nerve. 2011 Dec;44(6):877-81. doi: 10.1002/mus.22205.
INTRODUCTION
The aim of the study was to investigate the prevalence and risk factors of muscle complications among patients using statins.
METHODS
We conducted a prospective comparative study on 345 patients receiving statins and compared the findings with an age- and gender-matched control group of 85 subjects. Univariate and multivariate analyses with logistic regression models were used to study the association of different patient and disease characteristics with muscle complications.
RESULTS
Adverse reactions were reported by 21% of patients and 5.9% of controls (P = 0.0013). Objective weakness was found in 15% of the patients who reported muscle symptoms (3.2% of the total cohort), but not in controls. Older age, longer duration of statin use, diabetes, stroke, and lower body mass index were associated with increased risk of developing these symptoms.
CONCLUSIONS
Adverse reactions to statins may be more common than previously reported, and they may be affected by specific patient and disease characteristics.
简介
本研究旨在调查使用他汀类药物的患者发生肌肉并发症的患病率和风险因素。
方法
我们对 345 名接受他汀类药物治疗的患者进行了前瞻性对照研究，并将研究结果与 85 名年龄和性别匹配的对照组进行了比较。使用逻辑回归模型进行单因素和多因素分析，以研究不同患者和疾病特征与肌肉并发症之间的关联。
结果
21%的患者和 5.9%的对照组报告了不良反应（P=0.0013）。在报告肌肉症状的患者中，有 15%（总队列的 3.2%）出现了客观肌无力，但对照组没有。年龄较大、他汀类药物使用时间较长、糖尿病、中风和较低的体重指数与发生这些症状的风险增加相关。
结论
他汀类药物的不良反应可能比以前报告的更为常见，并且可能受到特定患者和疾病特征的影响。
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