Zhou Xiaohong, Wang Zixian, Qin Min, Zhong Shilong
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2020 Dec 30;40(12):1747-1752. doi: 10.12122/j.issn.1673-4254.2020.12.08.
To identify mitochondrial gene variants associated with statin-induced myalgia in Chinese patients with coronary artery disease (CHD).
This study was conducted in a cohort of 403 patients with CHD receiving rosuvastatin therapy, among whom 341 patients had complete follow-up data concerning myalgia and 389 patients had documented measurements of plasma creatine kinase (CK) level. All these patients underwent genetic analysis using GSA chip for detecting mitochondria gene variants associated with myalgia. A logistic regression model was used to assess the association between 69 mitochondrial single-nucleotide polymorphisms (SNPs) and myopathy in 341 patients. The impact of these mutation sites on CK levels in 389 patients was evaluated by linear regression analysis.
G12630A variant was identified to correlate with an increased risk of myalgia in CHD patients (OR: 8.689, 95% : 1.586-47.6; =0.01273), but CK levels did not differ significantly between patients with different genotypes of G12630A ( > 0.05). SNPs at T12285C and A13105G were found to significantly correlate with CK levels in these patients ( < 0.05).
Mitochondrial G12630A variation is associated with statin-induced myalgia in patients with CHD, indicating the necessity of different treatment strategies for patients who carry this risk allele.
确定中国冠心病（CHD）患者中与他汀类药物引起的肌痛相关的线粒体基因变异。
本研究在403例接受瑞舒伐他汀治疗的冠心病患者队列中进行，其中341例患者有关于肌痛的完整随访数据，389例患者有血浆肌酸激酶（CK）水平的记录测量值。所有这些患者均使用GSA芯片进行基因分析，以检测与肌痛相关的线粒体基因变异。采用逻辑回归模型评估341例患者中69个线粒体单核苷酸多态性（SNP）与肌病之间的关联。通过线性回归分析评估这些突变位点对389例患者CK水平的影响。
发现G12630A变异与冠心病患者肌痛风险增加相关（OR：8.689，95%：1.586 - 47.6；P = 0.01273），但不同G12630A基因型患者的CK水平差异无统计学意义（P > 0.05）。发现T12285C和A13105G处的SNP与这些患者的CK水平显著相关（P < 0.05）。
线粒体G12630A变异与冠心病患者他汀类药物引起的肌痛相关，这表明对携带该风险等位基因的患者有必要采取不同的治疗策略。
