Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, São Paulo 13083-970, Brazil.
Muscle Nerve. 2011 Dec;44(6):978-80. doi: 10.1002/mus.22235.
In this study we investigate whether dystrophic intrinsic laryngeal muscles (ILM) from aged mdx mice show alterations in dystrophin-glycoprotein complex (DGC) components.Immunofluorescence and immunoblotting analyses of beta-sarcoglycan, beta-dystroglycan, and utrophin showed that aged ILM had a similar pattern of changes in aged affected muscles (diaphragm and limb), suggesting that aging leads to changes in utrophin and DGC proteins in dystrophic ILM that cannot be correlated with their protection from dystrophic change.
在这项研究中，我们研究了衰老 mdx 小鼠的萎缩性内在喉肌 (ILM) 是否在肌营养不良蛋白聚糖复合物 (DGC) 成分中发生改变。β-肌聚糖、β-肌营养不良蛋白和 utrophin 的免疫荧光和免疫印迹分析表明，衰老的 ILM 在衰老的受影响肌肉（膈肌和四肢）中具有相似的变化模式，这表明衰老导致了 DGC 蛋白和 utrophin 在萎缩性 ILM 中的变化，而这些变化不能与其免受肌营养不良变化的保护相关联。
