Ajiro Hiroharu, Takemoto Yukie, Akashi Mitsuru
The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2, Yamada-oka, Suita, Osaka 565-0871, Japan.
J Nanosci Nanotechnol. 2011 Aug;11(8):7047-9. doi: 10.1166/jnn.2011.4239.
The swelling behaviors of IPN with poly(N-vinylacetamide) (PNVA), which possibly converts from nonionic gel to cationic gel, and the stimuli responsive polymers, such as poly(acrylic acid) (PAAc) and poly(N-isopropylacrylamide) (PNIPAm) were investigated in order to prepare the stimuli responsive amphiphilic gel. When the monomer concentrations were uniformed at the IPN preparation, the obtained PNVA/PAAc IPN showed the pH responsivity with around 100 of swelling ratio at pH 4 to around 1 of swelling ratio at pH 2, although it lost the amphiphilicity due to the lack of swelling in ethanol. On the other hand, the gelation of N-vinylacetamide at 2 M in PNIPAM gel resulted in thermosensitive and amphiphilic hydrogel, that the swelling ratio in EtOH/water (3/7, v/v) also decreased, compared to the value in water at 25 degrees C.
为了制备刺激响应性两亲凝胶，研究了聚（N-乙烯基乙酰胺）（PNVA）（其可能从非离子凝胶转变为阳离子凝胶）与刺激响应性聚合物，如聚丙烯酸（PAAc）和聚（N-异丙基丙烯酰胺）（PNIPAm）构成的互穿聚合物网络（IPN）的溶胀行为。当在IPN制备过程中使单体浓度均匀时，所得到的PNVA/PAAc IPN表现出pH响应性，在pH 4时溶胀率约为100，在pH 2时溶胀率约为1，尽管由于在乙醇中不溶胀而失去了两亲性。另一方面，在PNIPAM凝胶中2M的N-乙烯基乙酰胺的凝胶化产生了热敏性两亲水凝胶，与25℃水中的值相比，其在乙醇/水（3/7，v/v）中的溶胀率也降低了。
