Pediatric and Adolescent Endocrinology Department, Chair of Pediatrics, Jagiellonian University, Collegium Medicum, Krakow, Poland.
Clin Endocrinol (Oxf). 2012 Oct;77(4):537-40. doi: 10.1111/j.1365-2265.2011.04299.x.
Fibroblast growth factor-23 (FGF23) is a hormonal regulator of circulating phosphate and vitamin D levels. Recent investigations revealed that besides a key role in the pathogenesis of calcium-phosphorus disorders, in some patients FGF23 may be an indicator of cardiovascular complications. As a 'hormone-like' factor, it may also be involved in some metabolic processes, especially in the metabolism of glucose and fat. Its potential contribution to metabolic syndrome (MS) development has not been confirmed yet.
The study was to examine the possible correlations between FGF23 serum levels and body composition, blood pressure and selected parameters of glucose, insulin and fat metabolism in adolescents with simple obesity.
In 68 (35 female) adolescents (mean age 13·9 years) with simple obesity [mean BMI SDS 4·9 (95% CI 4·4-5·4)], the levels of FGF23, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides were measured. Standard oral glucose tolerance tests were performed with the assessment of fasting and after 120' postload glucose and insulin levels; the insulin resistance index HOMA-IR was calculated.
Regardless of gender, there was a significant inverse correlation between FGF23 and fasting insulin level (r = -0·3), as well as HOMA-IR (r = -0·29). Multiple regression model showed the independent association between FGF23 and HOMA-IR.
FGF23 seems to be a novel factor contributing to insulin sensitivity. Further investigations are needed to define its role in the development of MS.
成纤维细胞生长因子 23（FGF23）是一种调节循环磷酸盐和维生素 D 水平的激素。最近的研究表明，除了在钙磷代谢紊乱的发病机制中起关键作用外，在某些患者中，FGF23 可能是心血管并发症的一个指标。作为一种“类激素”因子，它也可能参与某些代谢过程，特别是葡萄糖和脂肪的代谢。其对代谢综合征（MS）发展的潜在贡献尚未得到证实。
本研究旨在探讨单纯性肥胖青少年血清 FGF23 水平与体成分、血压及血糖、胰岛素和脂肪代谢某些参数之间的可能相关性。
在 68 名（35 名女性）单纯性肥胖青少年（平均年龄 13.9 岁，BMI SDS 平均值为 4.9（95%CI 4.4-5.4））中，测定了 FGF23、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯的水平。进行标准口服葡萄糖耐量试验，评估空腹和 120' 餐后血糖和胰岛素水平；计算胰岛素抵抗指数 HOMA-IR。
无论性别如何，FGF23 与空腹胰岛素水平（r = -0.3）和 HOMA-IR（r = -0.29）呈显著负相关。多元回归模型显示 FGF23 与 HOMA-IR 之间存在独立关联。
FGF23 似乎是一个新的与胰岛素敏感性相关的因素。需要进一步研究以确定其在 MS 发展中的作用。
