Takashi Yuichi, Kawanami Daiji
Department of Endocrinology and Diabetes Mellitus, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Int J Mol Sci. 2022 Feb 21;23(4):2376. doi: 10.3390/ijms23042376.
Bone contributes to supporting the body, protecting the central nervous system and other organs, hematopoiesis, the regulation of mineral metabolism (mainly calcium and phosphate), and assists in respiration. Bone has many functions in the body. Recently, it was revealed that bone also works as an endocrine organ and secretes several systemic humoral factors, including fibroblast growth factor 23 (FGF23), osteocalcin (OC), sclerostin, and lipocalin 2. Bone can communicate with other organs via these hormones. In particular, it has been reported that these bone-derived hormones are involved in glucose metabolism and diabetic complications. Some functions of these bone-derived hormones can become useful biomarkers that predict the incidence of diabetes and the progression of diabetic complications. Furthermore, other functions are considered to be targets for the prevention or treatment of diabetes and its complications. As is well known, diabetes is now a worldwide health problem, and many efforts have been made to treat diabetes. Thus, further investigations of the endocrine system through bone-derived hormones may provide us with new perspectives on the prediction, prevention, and treatment of diabetes. In this review, we summarize the role of bone-derived hormones in glucose metabolism, diabetic kidney disease, and cardiovascular disorders.
骨骼有助于支撑身体、保护中枢神经系统和其他器官、进行造血、调节矿物质代谢（主要是钙和磷），并辅助呼吸。骨骼在身体中有多种功能。最近发现，骨骼还作为一种内分泌器官发挥作用，分泌多种全身性体液因子，包括成纤维细胞生长因子23（FGF23）、骨钙素（OC）、硬化蛋白和lipocalin 2。骨骼可通过这些激素与其他器官进行交流。特别是，据报道这些骨源性激素参与葡萄糖代谢和糖尿病并发症。这些骨源性激素的一些功能可成为预测糖尿病发病率和糖尿病并发症进展的有用生物标志物。此外，其他功能被认为是预防或治疗糖尿病及其并发症的靶点。众所周知，糖尿病现在是一个全球性的健康问题，人们已经为治疗糖尿病做出了很多努力。因此，通过骨源性激素对内分泌系统进行进一步研究可能会为我们提供关于糖尿病预测、预防和治疗的新视角。在这篇综述中，我们总结了骨源性激素在葡萄糖代谢、糖尿病肾病和心血管疾病中的作用。
