Center for Biochemistry and Center for Molecular Medicine Cologne, Medical Faculty, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Joseph-Stelzmann-Strasse 52, 50931 Cologne, Germany.
Biochem Soc Trans. 2011 Dec;39(6):1725-8. doi: 10.1042/BST20110668.
Nesprins (nuclear envelope spectrin repeat proteins), also known as SYNE (synaptic nuclear envelope protein), MYNE (myocyte nuclear envelope protein), ENAPTIN and NUANCE, are proteins that are primarily components of the nuclear envelope. The nuclear envelope is a continuous membrane system composed of two lipid bilayers: an inner and an outer nuclear membrane. Nesprins are components of both nuclear membranes and reach into the nucleoplasm and the cytoplasm, where they undergo different interactions and have the potential to influence transcriptional processes and cytoskeletal activities.
核膜斑蛋白（nesprins），又称为突触核膜蛋白（SYNE）、心肌核膜蛋白（MYNE）、ENAPTIN 和 NUANCE，是核膜的主要组成部分。核膜是由两层脂质双层组成的连续膜系统：内核膜和外核膜。核膜斑蛋白是两种核膜的组成部分，延伸到核质和细胞质中，在那里它们进行不同的相互作用，并有可能影响转录过程和细胞骨架活动。
