Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Avda. de Universidad s/n, 10003 Cáceres, Spain.
Biochem Soc Trans. 2011 Dec;39(6):1854-8. doi: 10.1042/BST20110706.
Pseudomonas pseudoalcaligenes CECT5344 can be used in cyanide bioremediation processes because it grows at pH 9.5 using 2.0 mM cyanide at the sole nitrogen source. Cyanide strongly binds to metals creating iron-deprivation conditions. The bacterium responds to the presence of cyanide by inducing several processes such as siderophore synthesis for iron capture, cyanide-insensitive respiration system and defence mechanisms against oxidative stress. Since high concentrations of cyanide cause iron deficiency and because iron is an essential nutrient, bacterial growth in the presence of cyanide requires an efficient iron uptake. Fur is a global transcription factor that regulates a diversity of biological processes such as iron homoeostasis, TCA (tricarboxylic acid) cycle metabolism and oxidative stress response. Fur's regulation of iron uptake and storage genes should play a significant role in the lives of these bacteria. In the present review, current knowledge of Fur is summarized.
铜绿假单胞菌 CECT5344 可以用于氰化物生物修复过程，因为它可以在 pH 值为 9.5 的条件下，以 2.0mM 的氰化物作为唯一氮源生长。氰化物与金属强烈结合，造成铁缺乏条件。细菌通过诱导几种过程来应对氰化物的存在，例如铁捕获的 siderophore 合成、氰化物不敏感的呼吸系统和抗氧化应激的防御机制。由于高浓度的氰化物会导致缺铁，而铁是一种必需的营养物质，因此在氰化物存在的情况下细菌的生长需要有效的铁摄取。Fur 是一种全局转录因子，它调节多种生物学过程，如铁同稳态、TCA（三羧酸循环）代谢和氧化应激反应。Fur 对铁摄取和储存基因的调节在这些细菌的生命中应该发挥重要作用。在本综述中，总结了 Fur 的现有知识。
