英夫利昔单抗治疗坏疽性脓皮病后 IgA 血症进展为骨髓瘤。

Progression of IgA gammopathy to myeloma following infliximab treatment for pyoderma gangrenosum.

机构信息

Department of Dermatology, York Teaching Hospital, York, UK.

出版信息

Clin Exp Dermatol. 2012 Mar;37(2):146-8. doi: 10.1111/j.1365-2230.2011.04219.x. Epub 2011 Nov 21.

DOI:10.1111/j.1365-2230.2011.04219.x

Abstract

Pyoderma gangrenosum (PG) may be associated with inflammatory disorders and haematological conditions such as monoclonal gammopathy of uncertain significance (MGUS). We report the case of a 53-year old man who had PG and MGUS. After treatment with infliximab for the PG, he developed myeloma. The course of events in this case suggests that infliximab facilitated the progression from MGUS to myeloma.

摘要

坏疽性脓皮病（PG）可能与炎症性疾病和血液疾病有关，如意义未明的单克隆丙种球蛋白血症（MGUS）。我们报告了一例 53 岁男性患有 PG 和 MGUS 的病例。在 PG 接受英夫利昔单抗治疗后，他发展为骨髓瘤。这种情况下的事件过程表明，英夫利昔单抗促进了从 MGUS 向骨髓瘤的进展。