生命早期感染与社区青少年精神障碍的关联：一项横断面研究。
Association between infection early in life and mental disorders among youth in the community: a cross-sectional study.
机构信息
Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Rm 1505, New York, NY 10032, USA.
出版信息
BMC Public Health. 2011 Nov 21;11:878. doi: 10.1186/1471-2458-11-878.
BACKGROUND
The objective of this study was to examine the association between infection early in life and mental disorders among youth in the community.
METHODS
Data were drawn from the MECA (Methods in Epidemiology of Child and Adolescent psychopathology), a community-based study of 1,285 youth in the United States conducted in 1992. Multiple logistic regression analyses were used to investigate the association between parent/caregiver-reported infection early in life and DSM/DISC diagnoses of mental disorders at ages 9-17.
RESULTS
Infection early in life was associated with a significantly increased odds of major depression (OR = 3.9), social phobia (OR = 5.8), overanxious disorder (OR = 6.1), panic disorder (OR = 12.1), and oppositional defiant disorder (OR = 3.7).
CONCLUSIONS
These findings are consistent with and extend previous results by providing new evidence suggesting a link between infection early in life and increased risk of depression and anxiety disorders among youth. These results should be considered preliminary. Replication of these findings with longitudinal epidemiologic data is needed. Possible mechanisms are discussed.
背景
本研究旨在探讨生命早期感染与社区青少年精神障碍之间的关系。
方法
数据来自于 MECA（儿童和青少年精神病理学的流行病学方法），这是一项基于社区的研究，共纳入美国 1285 名青少年，于 1992 年进行。采用多因素逻辑回归分析来调查生命早期父母/照料者报告的感染与 9-17 岁时 DSM/DISC 精神障碍诊断之间的关系。
结果
生命早期感染与重度抑郁（OR=3.9）、社交恐惧症（OR=5.8）、过度焦虑症（OR=6.1）、恐慌症（OR=12.1）和对立违抗性障碍（OR=3.7）的患病风险显著增加有关。
结论
这些发现与既往研究结果一致，为生命早期感染与青少年抑郁和焦虑障碍风险增加之间的联系提供了新的证据。这些结果应被视为初步结果。需要使用纵向流行病学数据对这些发现进行复制。还讨论了可能的机制。
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