Department of Surgical Sciences, Organ Transplantation, and Advanced Technologies, University of Catania, Cannizzaro Hospital, Via Messina 829, 95126 Catania, Italy.
Surg Oncol. 2012 Mar;21(1):e23-30. doi: 10.1016/j.suronc.2011.10.005. Epub 2011 Nov 21.
Aim of this work was to compare quality of life (QoL) of patients affected by HCC and submitted to hepatic resection (HR), transarterial chemoembolization (TACE), radiofrequency ablation (RFA), or no treatment (NT).
Patients affected by HCC between 2001 and 2009 were considered for this study. Gender, diabetes, hepatitis status, Child grade, tumor size, and recurrence were analyzed. QoL was assessed before treatment and 3, 6, 12, and 24 months after, using a FACT-Hep questionnaire. P value was considered significant if <0.01 and highly significant if <0.001.
Fourteen patients (27.45%) were treated with HR, 15 patients (29.41%) underwent TACE, RFA was performed in 9 patients (17.65%), and 13 patients (25.49%) were not treated. Physical well-being, social/family well-being, emotional well-being, functional well-being and additional concerns 24 months after HR were significantly higher compared to all other treatments.
Hepatic resection provides the best QoL at 24 months. RFA provides a worse QoL compared to HR, but a higher QoL compared to TACE or NT.
本研究旨在比较接受肝切除术（HR）、经动脉化疗栓塞术（TACE）、射频消融术（RFA）或未治疗（NT）的 HCC 患者的生活质量（QoL）。
研究纳入了 2001 年至 2009 年间的 HCC 患者。分析了性别、糖尿病、肝炎状态、Child 分级、肿瘤大小和复发情况。使用 FACT-Hep 问卷在治疗前和治疗后 3、6、12 和 24 个月评估 QoL。P 值<0.01 为有统计学意义，<0.001 为高度显著。
14 例患者（27.45%）接受 HR 治疗，15 例患者（29.41%）接受 TACE 治疗，9 例患者（17.65%）接受 RFA 治疗，13 例患者（25.49%）未治疗。HR 治疗后 24 个月的身体状况、社会/家庭状况、情绪状况、功能状况和其他方面的担忧显著高于其他所有治疗。
肝切除术在 24 个月时提供最佳的 QoL。RFA 与 HR 相比提供较差的 QoL，但与 TACE 或 NT 相比提供更好的 QoL。
