Department of Radiology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Eur J Radiol. 2012 Oct;81(10):2801-4. doi: 10.1016/j.ejrad.2011.10.011. Epub 2011 Nov 21.
To evaluate the effect of normal aging on brain volumes and examine the effects of age and sex on the rates of changes in global and regional brain volumes.
A total of 199 normal subjects (65 females and 134 males, mean age=56.4 ± 9.9 years, age range=38.1-82.9 years) were included in this study. Each subject was scanned twice, at an interval of about 2 years (range=1.5-2.3 years). Two-time-point percentage brain volume change (PBVC) was estimated with SIENA 2.6.
The mean annualized PBVC was -0.23%/y. Analysis of covariance (ANCOVA) for annual brain volume changes revealed a main effect of age. There was no main effect of sex, nor was there a sex-by-age interaction. Voxel-wise analysis revealed a negative correlation between age and edge displacement values mainly in the periventricular region.
The results of our study indicate that brain atrophy accelerates with increasing age and that there is no gender difference in the rate of brain atrophy.
评估正常衰老对脑容量的影响，并考察年龄和性别对全脑和各脑区体积变化率的影响。
本研究共纳入 199 名正常受试者（65 名女性和 134 名男性，平均年龄=56.4±9.9 岁，年龄范围 38.1-82.9 岁）。每位受试者均接受了两次扫描，两次扫描之间的间隔约为 2 年（范围 1.5-2.3 年）。使用 SIENA 2.6 估计两次扫描间的脑容量百分比变化（PBVC）。
平均每年 PBVC 为-0.23%/y。协方差分析（ANCOVA）显示，脑体积的年度变化主要与年龄有关。性别无主效应，也不存在性别与年龄的交互作用。体素-wise 分析显示，年龄与边缘位移值呈负相关，主要位于脑室周围区域。
本研究结果表明，脑萎缩随年龄增长而加速，且脑萎缩的速度在性别间无差异。
