Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
J Autism Dev Disord. 2012 Aug;42(8):1630-41. doi: 10.1007/s10803-011-1402-y.
Epilepsy co-occurs frequently in autism spectrum disorders (ASD). Understanding this co-occurrence requires a better understanding of the ASD-epilepsy phenotype (or phenotypes). To address this, we conducted latent class cluster analysis (LCCA) on an ASD dataset (N = 577) which included 64 individuals with epilepsy. We identified a 5-cluster solution with one cluster showing a high rate of epilepsy (29%), earlier age at first recognition, and high rates of repetitive object use and unusual sensory interests. We also conducted LCCA on an ASD-epilepsy subset from the overall dataset (N = 64) which yielded three clusters, the largest of which had impairments in language and motor development; the remaining clusters, while not as developmentally impaired were characterized by different levels of repetitive and sensory behaviors.
癫痫在自闭症谱系障碍（ASD）中经常同时发生。要理解这种同时发生，需要更好地了解 ASD-癫痫表型（或表型）。为此，我们对一个包含 64 名癫痫患者的 ASD 数据集（N=577）进行了潜在类别聚类分析（LCCA）。我们确定了一个具有 5 个聚类的解决方案，其中一个聚类显示出高癫痫发病率（29%）、首次识别的年龄较早、重复物体使用和异常感觉兴趣的发生率较高。我们还对整个数据集（N=64）中的 ASD-癫痫亚组进行了 LCCA，得出了三个聚类，其中最大的聚类在语言和运动发育方面存在障碍；其余的聚类虽然在发育方面没有那么受损，但具有不同程度的重复和感觉行为特征。
