Reilly Colin, Atkinson Patricia, Das Krishna B, Chin Richard F M, Aylett Sarah E, Burch Victoria, Gillberg Christopher, Scott Rod C, Neville Brian G R
Research Department, Young Epilepsy, Lingfield, Surrey RH7 6PW, UK; Gillberg Neuropsychiatry Centre, University of Gothenburg, Kungsgatan 12, Gothenburg, Sweden.
Child Development Centre, Crawley Hospital, West Green Drive, Crawley, RH11 7DH West Sussex, UK.
Epilepsy Behav. 2015 Jan;42:86-92. doi: 10.1016/j.yebeh.2014.11.014. Epub 2014 Dec 16.
In a defined geographical area in the south of the UK, 115 children with active epilepsy (i.e., children who had seizures in the last year and/or children who were taking antiepileptic drugs (AEDs)) were identified via a computerized database and liaison with local pediatricians. Eighty-five (74%) of the children (5-15years of age) underwent a comprehensive psychological assessment. Twenty-one percent of the children met the DSM-IV-TR criteria for ASD, and 61% of those with ASD had another DSM-IV-TR behavioral or motor disorder. The Autism Spectrum Screening Questionnaire (ASSQ) was completed by parents (n=69) and by teachers (n=67) of children with an IQ>34. Only 9% of children on parent ratings and 15% of children on teacher ratings had no features of ASD. Parents reported significantly (p<.05) more features of ASD on the ASSQ compared with teachers. Factors significantly associated with responses on the ASSQ included respondent (parents reported more features), school placement (more features in specialized settings), and respondent by school placement interaction. Effective screening for ASD in children with epilepsy will need a consideration of the impact of informant and school placement on ratings. In conclusion, features of ASD were common in children with epilepsy regardless of cognitive ability. The ASSQ was a useful screening instrument in this population, and combining parent and teacher forms was optimal in terms of screening properties.
在英国南部一个特定的地理区域，通过计算机数据库并与当地儿科医生联系，确定了115名患有活动性癫痫的儿童（即过去一年有癫痫发作的儿童和/或正在服用抗癫痫药物（AEDs）的儿童）。其中85名（74%）儿童（5至15岁）接受了全面的心理评估。21%的儿童符合DSM-IV-TR自闭症谱系障碍（ASD）标准，且61%患有ASD的儿童还患有另一种DSM-IV-TR行为或运动障碍。自闭症谱系筛查问卷（ASSQ）由智商>34的儿童的家长（n = 69）和教师（n = 67）填写。在家长评分中，只有9%的儿童没有ASD特征；在教师评分中，只有15%的儿童没有ASD特征。与教师相比，家长在ASSQ上报告的ASD特征明显更多（p<.05）。与ASSQ回答显著相关的因素包括回答者（家长报告的特征更多）、学校安置（在特殊环境中有更多特征）以及回答者与学校安置的交互作用。对癫痫儿童进行有效的ASD筛查需要考虑报告者和学校安置对评分的影响。总之，无论认知能力如何，ASD特征在癫痫儿童中都很常见。ASSQ是该人群中一种有用的筛查工具，就筛查特性而言，将家长和教师的表格结合起来是最佳的。
