Scheiffarth O F, Tang S, Kampik A
Universitäts-Augenklinik, München.
Fortschr Ophthalmol. 1990;87(4):340-3.
Macrophages and macrophage-like cells have been reported as cellular components of epiretinal and vitreous membranes. The origin and function of these versatile cells in the membranes are not fully understood. In the present study we used monoclonal antibodies reacting with macrophages, HLA-DR and monocytes (OKM5) to investigate cells in 52 specimens of various human epiretinal and vitreous membranes collected by vitrectomy. The results show that more than 80% of all membranes are positive for macrophage and HLA-DR antigen. HLA-DR is considered to be expressed by the macrophages. Cells reacting with antimonocyte (OKM5) are seen sporadically only in proliferative diabetic retinopathy. These results are discussed with respect to the possible origin of the macrophages and their important role in the development and formation of epiretinal and vitreal membranes.
巨噬细胞和类巨噬细胞已被报道为视网膜前膜和玻璃体膜的细胞成分。这些多功能细胞在膜中的起源和功能尚未完全明确。在本研究中，我们使用与巨噬细胞、HLA - DR和单核细胞反应的单克隆抗体（OKM5），对通过玻璃体切除术收集的52份不同人类视网膜前膜和玻璃体膜标本中的细胞进行研究。结果显示，所有膜标本中超过80%的巨噬细胞和HLA - DR抗原呈阳性。HLA - DR被认为是由巨噬细胞表达的。仅在增殖性糖尿病视网膜病变中偶尔可见与抗单核细胞（OKM5）反应的细胞。结合巨噬细胞可能的起源及其在视网膜前膜和玻璃体膜形成与发展中的重要作用对这些结果进行了讨论。
