Golubović S, Parunović A
Universitäts-Augenklinik, Belgrad, Yugoslawein.
Fortschr Ophthalmol. 1990;87(4):378-81.
The application of tissue adhesives to treat different corneal diseases has been used extensively in recent years. Owing to the widespread application, it has been possible to establish the advantages and disadvantages of this method of treatment. Keeping in mind the disadvantages (primarily the toxicity of cyanoacrylate glue for the corneal endothelium and lens when it comes into direct contact with these structures), the application of cyanoacrylate glue was restricted to the treatment of progressive corneal ulcerations where the risk of corneal perforation was recognized. This method of treatment was applied in 30 patients with corneal melting in dry eye associated with rheumatoid arthritis (12), trophic postherpetic ulcerations of the cornea (9), chemical corneal burns (7), neurotrophic corneal ulceration (1) and Mooren's ulcer (1). The defect healed and anterior corneal surface epithelization occurred in 73.33% of patients in contrast to the additional treatment, most commonly penetrating keratoplasty, required in the remaining patients (26.67%).
近年来，组织粘合剂在治疗不同角膜疾病中的应用已得到广泛使用。由于其广泛应用，得以明确这种治疗方法的优缺点。鉴于其缺点（主要是氰基丙烯酸酯胶水与角膜内皮和晶状体直接接触时对它们的毒性），氰基丙烯酸酯胶水的应用仅限于治疗已认识到有角膜穿孔风险的进行性角膜溃疡。该治疗方法应用于30例患有与类风湿性关节炎相关的干眼性角膜溶解（12例）、角膜营养性疱疹后溃疡（9例）、化学性角膜烧伤（7例）、神经营养性角膜溃疡（1例）和蚕蚀性角膜溃疡（1例）的患者。与其余患者（26.67%）通常需要额外治疗（最常见的是穿透性角膜移植术）相比，73.33%的患者缺损愈合且角膜前表面上皮化。
