Fujimoto Hiroki, Asai Kazuhisa, Watanabe Tetsuya, Kanazawa Hiroshi, Hirata Kazuto
Department of Respiratory Medicine, Osaka City University, Graduate School of Medicine, Osaka, Japan.
Osaka City Med J. 2011 Jun;57(1):21-9.
The six-minute walk test (6MWT) is widely used for integrated assessment of patients with chronic obstructive pulmonary disease (COPD). However, little is known concerning which resting pulmonary function test measurements relate to six-minute walk distance (6MWD).
We retrospectively analyzed consecutive data of spirometry, lung volume analysis, and measurements of diffusing capacity of the lung for carbon monoxide (DLCO) and 6MWT from total of one-hundred and thirty patients with COPD. Univariate and multivariate analyses were performed to examine the relationships between 6MWD and variables.
By linear regression analysis, 6MWD was significantly associated with age, weight, BMI, FEV1.0, FEV1.0 (% predicted), IC, TLC, IC/TLC, FEF25-75, DLCO (% predicted), and DLCO/VA. Stepwise multiple regression analysis revealed that age (r2 = 0.173; p < 0.0001), IC (r2 = 0.18; p < 0.0001), and DLCONA (r2 = 0.238; p < 0.0001) significantly accounted for 6MWD.
The present results suggest that age, IC, and DLCONA were significantly associated with 6MWD in patients with COPD.
六分钟步行试验（6MWT）广泛用于慢性阻塞性肺疾病（COPD）患者的综合评估。然而，关于哪些静息肺功能测试指标与六分钟步行距离（6MWD）相关，目前知之甚少。
我们回顾性分析了130例COPD患者的肺活量测定、肺容积分析、一氧化碳弥散量（DLCO）测量及6MWT的连续数据。进行单因素和多因素分析以检验6MWD与各变量之间的关系。
通过线性回归分析，6MWD与年龄、体重、体重指数、第1秒用力呼气容积（FEV1.0）、FEV1.0（预计值%）、吸气量（IC）、肺总量（TLC）、IC/TLC、25%~75%用力呼气流量（FEF25-75）、DLCO（预计值%）及DLCO/肺泡容积（VA）显著相关。逐步多元回归分析显示，年龄（r2 = 0.173；p < 0.0001）、IC（r2 = 0.18；p < 0.0001）及校正后DLCO（r2 = 0.238；p < 0.0001）可显著解释6MWD。
目前结果表明，年龄、IC及校正后DLCO与COPD患者的6MWD显著相关。
