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热熔胶层厚度对泡罩包装质量的影响。

Influences of heat seal lacquer thickness on the quality of blister packages.

机构信息

Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University of Mainz, Staudinger Weg 5, 55099 Mainz, Germany.

出版信息

Eur J Pharm Sci. 2012 Jan 23;45(1-2):150-7. doi: 10.1016/j.ejps.2011.11.006. Epub 2011 Nov 16.

Abstract

A sealability of aluminium lidding foils against formable polymer materials of blister packages is usually achieved by a coating of aluminium with certain grammages of heat seal lacquers. To investigate influences of their thickness on quality of blister packages, lidding foils with different grammages of two lacquer types were manufactured. Sealing experiments (variation of temperature, pressure and sealing time) were performed. Sealed seam strengths were determined with mechanical tensile tests, tightness of cold form blisters were analysed by means of helium leakage tests. Time-dependent moisture uptake of stored blisters was monitored with micro-gas chromatography. By means of a simple calculation model the permeability coefficients of the heat seal lacquers were determined. Lidding foils with higher lacquer grammages showed significantly greater sealed seam strengths. Helium leakage tests showed only slight effects of heat seal lacquer grammage on tightness of blisters. But cold form blisters with lidding foils of higher lacquer grammages showed a significantly greater moisture uptake. Since the heat seal lacquers and the rigid polyvinyl chloride of the formable aluminium compound foils had similar permeability coefficients, the contribution of the lacquers to the total permeability of the investigated cold form blisters was only slightly.

摘要

铝密封箔对泡罩包装的可成型聚合物材料的密封性通常通过在铝上涂覆一定克重的热封漆来实现。为了研究其厚度对泡罩包装质量的影响,使用两种不同类型的漆制造了不同克重的密封箔。进行了密封实验(温度、压力和密封时间的变化)。使用机械拉伸试验测定密封焊缝强度,通过氦气泄漏试验分析冷成型泡罩的密封性。使用微气相色谱法监测储存泡罩的水分吸收随时间的变化。通过一个简单的计算模型确定了热封漆的渗透系数。具有较高漆克重的密封箔显示出明显更大的密封焊缝强度。氦气泄漏试验仅显示出热封漆克重对泡罩密封性的轻微影响。但是,具有较高漆克重的密封箔的冷成型泡罩显示出明显更大的水分吸收。由于热封漆和可成型铝复合箔的刚性聚氯乙烯具有相似的渗透系数,因此在研究的冷成型泡罩的总渗透率中,漆的贡献仅略大。

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