扩增受阻突变系统快速检测 blaIMP-6
Rapid detection of blaIMP-6 by amplification refractory mutation system.
机构信息
Project Research Center for Nosocomial Infectious Disease, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan.
出版信息
J Microbiol Methods. 2012 Jan;88(1):182-4. doi: 10.1016/j.mimet.2011.10.022. Epub 2011 Nov 15.
PMID:22108497
Abstract
Klebsiella pneumoniae resistant to almost all ß-lactams except imipenem designated as ISMRK (imipenem-susceptible meropenem-resistant Klebsiella) is emerging in Japan. All ISMRK carries bla(IMP-6) which differs from bla(IMP-1) by only a single nucleotide at position 640. We devised a rapid detection system of bla(IMP-6) by using ARMS PCR.
摘要
在日本，除亚胺培南以外几乎对所有β-内酰胺类抗生素耐药的肺炎克雷伯菌被指定为 ISMRK（亚胺培南敏感美罗培南耐药肺炎克雷伯菌），这种 ISMRK 携带 bla(IMP-6)，其与 bla(IMP-1) 仅在 640 位的一个核苷酸上存在差异。我们设计了一种使用 ARMS-PCR 的 bla(IMP-6)快速检测系统。
Zotero 插件