• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

耐亚胺培南美罗培南敏感但快速自动检测系统检测不出耐药的肺炎克雷伯菌分离株的耐美罗培南现象。

Meropenem resistance in imipenem-susceptible meropenem-resistant Klebsiella pneumoniae isolates not detected by rapid automated testing systems.

机构信息

Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Minami-ku, Hiroshima City, Hiroshima, Japan.

出版信息

J Clin Microbiol. 2013 Aug;51(8):2735-8. doi: 10.1128/JCM.02649-12. Epub 2013 May 29.

DOI:10.1128/JCM.02649-12
PMID:23720796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3719643/
Abstract

Klebsiella pneumoniae showing high resistance to all β-lactams except imipenem, designated as ISMRK (imipenem-susceptible meropenem-resistant Klebsiella) is emerging in Japan. The carbapenem resistance of ISMRK cannot be screened by the Vitek and the RAISUS rapid automated susceptibility test systems, which may lead to inappropriate antimicrobial therapy, resulting in compromised patient outcomes.

摘要

产碳青霉烯酶肺炎克雷伯菌（Klebsiella pneumoniae）除亚胺培南（imipenem）外，对所有β-内酰胺类抗菌药物均高度耐药，被命名为 ISMRK（亚胺培南敏感美罗培南耐药肺炎克雷伯菌），在日本不断出现。Vitek 和 RAISUS 快速自动化药敏检测系统无法筛选出 ISMRK 的碳青霉烯酶耐药性，这可能导致抗菌药物治疗不当，从而影响患者的治疗效果。

相似文献

1
Meropenem resistance in imipenem-susceptible meropenem-resistant Klebsiella pneumoniae isolates not detected by rapid automated testing systems.耐亚胺培南美罗培南敏感但快速自动检测系统检测不出耐药的肺炎克雷伯菌分离株的耐美罗培南现象。
J Clin Microbiol. 2013 Aug;51(8):2735-8. doi: 10.1128/JCM.02649-12. Epub 2013 May 29.
2
Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6.在日本出现了一株对亚胺培南敏感、对美罗培南耐药的携带 blaIMP-6 的肺炎克雷伯菌。
Diagn Microbiol Infect Dis. 2012 Jan;72(1):109-12. doi: 10.1016/j.diagmicrobio.2011.09.019. Epub 2011 Nov 10.
3
Carbapenem resistance in Klebsiella pneumoniae not detected by automated susceptibility testing.自动药敏试验未检测到肺炎克雷伯菌对碳青霉烯类药物的耐药性。
Emerg Infect Dis. 2006 Aug;12(8):1209-13. doi: 10.3201/eid1208.060291.
4
[Investigation of the susceptibilities of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella spp. strains to ertapenem and other carbapenems].产超广谱β-内酰胺酶大肠埃希菌和克雷伯菌属菌株对厄他培南及其他碳青霉烯类药物的敏感性研究
Mikrobiyol Bul. 2011 Jan;45(1):28-35.
5
Rapid detection of blaIMP-6 by amplification refractory mutation system.扩增受阻突变系统快速检测 blaIMP-6
J Microbiol Methods. 2012 Jan;88(1):182-4. doi: 10.1016/j.mimet.2011.10.022. Epub 2011 Nov 15.
6
Discrepancies and interpretation problems in susceptibility testing of VIM-1-producing Klebsiella pneumoniae isolates.产VIM-1型肺炎克雷伯菌分离株药敏试验中的差异及解释问题。
J Clin Microbiol. 2005 Jan;43(1):494-6. doi: 10.1128/JCM.43.1.494-496.2005.
7
Study of Synergistic Bactericidal Activity of Dual β-Lactam Antibiotics Against KPC-2-Producing .产 KPC-2 酶肠杆菌科细菌中两种β-内酰胺类抗生素协同杀菌活性的研究
Microb Drug Resist. 2020 Mar;26(3):204-210. doi: 10.1089/mdr.2019.0126. Epub 2019 Sep 25.
8
First isolation of a VIM-producing Klebsiella pneumoniae from a seven-year-old child in Venezuela.在委内瑞拉，首次从一名七岁儿童体内分离出产VIM的肺炎克雷伯菌。
J Infect Dev Ctries. 2008 Jun 1;2(3):241-4. doi: 10.3855/jidc.270.
9
The first case of septicemia caused by imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae.首例由对亚胺培南敏感、对美罗培南耐药的肺炎克雷伯菌引起的败血症病例。
Ann Lab Med. 2013 Sep;33(5):383-5. doi: 10.3343/alm.2013.33.5.383. Epub 2013 Aug 8.
10
In vitro activity of fosfomycin in combination with imipenem, meropenem, colistin and tigecycline against OXA 48-positive Klebsiella pneumoniae strains.体外研究磷霉素联合亚胺培南、美罗培南、黏菌素和替加环素对产 OXA-48 阳性肺炎克雷伯菌的活性。
Diagn Microbiol Infect Dis. 2013 Jul;76(3):335-8. doi: 10.1016/j.diagmicrobio.2013.04.004. Epub 2013 May 29.

引用本文的文献

1
Reporting antimicrobial susceptibility and detection of carbapenemase production in single and double carbapenemase-producing Gram-negative clinical isolates: a nationwide proficiency study.单产碳青霉烯酶和双产碳青霉烯酶革兰阴性临床分离株的抗菌药物敏感性报告及碳青霉烯酶产生情况检测：一项全国性能力验证研究
Front Microbiol. 2025 Jun 10;16:1605590. doi: 10.3389/fmicb.2025.1605590. eCollection 2025.
2
The Novel CarbaLux Test for Carbapenemases and Carbapenem Deactivating AmpC Beta-Lactamases.用于检测碳青霉烯酶和碳青霉烯失活AmpCβ-内酰胺酶的新型CarbaLux检测法
Front Microbiol. 2020 Nov 23;11:588887. doi: 10.3389/fmicb.2020.588887. eCollection 2020.
3
Rampant spread of infection in an afebrile immune-competent patient presenting with young-onset ischaemic stroke.发热症状不明显的免疫功能正常的年轻起病缺血性脑卒中患者感染迅速蔓延。
BMJ Case Rep. 2020 Aug 25;13(8):e235495. doi: 10.1136/bcr-2020-235495.
4
Suitability of Carbapenem Inactivation Method (CIM) for Detection of IMP Metallo-β-Lactamase-Producing Enterobacteriaceae.碳青霉烯灭活法（CIM）用于检测产IMP金属β-内酰胺酶肠杆菌科细菌的适用性
J Clin Microbiol. 2017 Apr;55(4):1220-1222. doi: 10.1128/JCM.02275-16. Epub 2017 Jan 18.
5
The emergence of carbapenem resistant in Malaysia: correlation between microbiological trends with host characteristics and clinical factors.马来西亚碳青霉烯耐药菌的出现：微生物学趋势与宿主特征及临床因素之间的相关性。
Antimicrob Resist Infect Control. 2017 Jan 7;6:5. doi: 10.1186/s13756-016-0164-x. eCollection 2017.
6
Performance evaluation of three automated identification systems in detecting carbapenem-resistant Enterobacteriaceae.三种自动识别系统检测耐碳青霉烯类肠杆菌科细菌的性能评估
Ann Clin Microbiol Antimicrob. 2016 Jun 21;15(1):40. doi: 10.1186/s12941-016-0154-0.
7
Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in Japan.来自日本新出现的耐碳青霉烯肠杆菌科细菌的编码IMP-6和CTX-M-2的IncN质粒的完整核苷酸序列。
Antimicrob Agents Chemother. 2015 Feb;59(2):1356-9. doi: 10.1128/AAC.04759-14. Epub 2014 Dec 8.
8
Evaluation of the vitek 2 AST-N269 card for detection of meropenem resistance in imipenem-susceptible meropenem-resistant Enterobacteriaceae.评估Vitek 2 AST-N269卡片检测对亚胺培南敏感但对美罗培南耐药的肠杆菌科细菌中耐美罗培南情况的能力。
J Clin Microbiol. 2013 Nov;51(11):3908. doi: 10.1128/JCM.02063-13. Epub 2013 Aug 21.

本文引用的文献

1
Emergence in Japan of an imipenem-susceptible, meropenem-resistant Klebsiella pneumoniae carrying blaIMP-6.在日本出现了一株对亚胺培南敏感、对美罗培南耐药的携带 blaIMP-6 的肺炎克雷伯菌。
Diagn Microbiol Infect Dis. 2012 Jan;72(1):109-12. doi: 10.1016/j.diagmicrobio.2011.09.019. Epub 2011 Nov 10.
2
Comparison of BD Phoenix, Vitek 2, and MicroScan automated systems for detection and inference of mechanisms responsible for carbapenem resistance in Enterobacteriaceae.比较 BD Phoenix、Vitek 2 和 MicroScan 自动化系统在检测和推断肠杆菌科碳青霉烯类耐药机制中的作用。
J Clin Microbiol. 2010 Aug;48(8):2999-3002. doi: 10.1128/JCM.00341-10. Epub 2010 Jun 9.
3
Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection.产碳青霉烯酶肺炎克雷伯菌（KPCs）的检测与治疗选择：一种多重耐药感染的新兴病因。
J Antimicrob Chemother. 2010 Jun;65(6):1119-25. doi: 10.1093/jac/dkq108. Epub 2010 Apr 8.
4
Antimicrobial susceptibility testing: a review of general principles and contemporary practices.抗菌药物敏感性测试：一般原则和当代实践的综述。
Clin Infect Dis. 2009 Dec 1;49(11):1749-55. doi: 10.1086/647952.
5
Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae.评估肠杆菌科细菌中肺炎克雷伯菌碳青霉烯酶的鉴定方法。
J Clin Microbiol. 2007 Aug;45(8):2723-5. doi: 10.1128/JCM.00015-07. Epub 2007 Jun 20.
6
Carbapenem resistance in Klebsiella pneumoniae not detected by automated susceptibility testing.自动药敏试验未检测到肺炎克雷伯菌对碳青霉烯类药物的耐药性。
Emerg Infect Dis. 2006 Aug;12(8):1209-13. doi: 10.3201/eid1208.060291.
7
Assessment of RAISUS, a novel system for identification and antimicrobial susceptibility testing for enterococci.RAISUS评估：一种用于肠球菌鉴定和抗菌药敏试验的新型系统。
Diagn Microbiol Infect Dis. 2005 Sep;53(1):23-7. doi: 10.1016/j.diagmicrobio.2005.04.008.
8
Emergence of KPC-possessing Klebsiella pneumoniae in Brooklyn, New York: epidemiology and recommendations for detection.纽约布鲁克林产肺炎克雷伯菌碳青霉烯酶（KPC）的肺炎克雷伯菌的出现：流行病学及检测建议
Antimicrob Agents Chemother. 2005 Jul;49(7):3018-20. doi: 10.1128/AAC.49.7.3018-3020.2005.
9
Clinical and financial benefits of rapid bacterial identification and antimicrobial susceptibility testing.快速细菌鉴定和抗菌药敏试验的临床及经济效益
J Clin Microbiol. 1999 May;37(5):1415-8. doi: 10.1128/JCM.37.5.1415-1418.1999.
10
Clinical impact of rapid in vitro susceptibility testing and bacterial identification.快速体外药敏试验和细菌鉴定的临床影响。
J Clin Microbiol. 1994 Jul;32(7):1757-62. doi: 10.1128/jcm.32.7.1757-1762.1994.