Kaira Kyoichi, Nakagawa Kazuo, Ohde Yasuhisa, Okumura Takehiro, Takahashi Toshiaki, Murakami Haruyasu, Endo Masahiro, Kondo Haruhiko, Nakajima Takashi, Yamamoto Nobuyuki
Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Int J Surg Pathol. 2012 Jun;20(3):223-32. doi: 10.1177/1066896911429296. Epub 2011 Nov 21.
MUC1 is transmembrane mucin aberrantly overexpressed in various cancers. However, little is known about how MUC1 expression is associated with hypoxia, glucose metabolism, and epidermal growth factor receptor (EGFR) pathway, which are related to cancer progression. The aim of this study is to evaluate the relationship between MUC1 expression and these molecular markers in lung cancer. Of all 126 patients, high-grade polarized expression (HP), low-grade polarized expression (LP), and depolarized expression (DP) group were 50 (39.7%), 35 (27.8%), and 41 (32.5%), respectively. Depolarized MUC1 expression was significantly associated with poor outcome and was closely correlated with glucose metabolism (Glut1), hypoxia (HIF-1α), angiogenesis (vascular endothelial growth factor and microvessel density), amino acid metabolism (LAT1), and EGFR expression. High-grade polarized MUC1 expression was associated with favorable prognosis and adenocarcinoma. Depolarized MUC1 expression was significantly associated with poor outcome. Glucose metabolism, hypoxia, angiogenesis, amino acid metabolism, and EGFR pathway may play an important role in the development of depolarized MUC1 expression.
MUC1是一种跨膜粘蛋白，在多种癌症中异常过度表达。然而，关于MUC1表达如何与缺氧、葡萄糖代谢和表皮生长因子受体（EGFR）通路相关联，人们知之甚少，而这些因素都与癌症进展有关。本研究的目的是评估肺癌中MUC1表达与这些分子标志物之间的关系。在所有126例患者中，高分化极性表达（HP）组、低分化极性表达（LP）组和去极化表达（DP）组分别有50例（39.7%）、35例（27.8%）和41例（32.5%）。去极化的MUC1表达与不良预后显著相关，并且与葡萄糖代谢（Glut1）、缺氧（HIF-1α）、血管生成（血管内皮生长因子和微血管密度）、氨基酸代谢（LAT1）以及EGFR表达密切相关。高分化极性MUC1表达与良好预后及腺癌相关。去极化的MUC1表达与不良预后显著相关。葡萄糖代谢、缺氧、血管生成、氨基酸代谢和EGFR通路可能在去极化MUC1表达的发生发展中起重要作用。
