Escola Bahiana de Medicina e Saúde Pública, Salvador, BA, Brazil.
Qual Life Res. 2012 Nov;21(9):1545-50. doi: 10.1007/s11136-011-0066-6. Epub 2011 Nov 23.
A previous study found the prevalence of depression in HTLV-1-infected patients to be approximately 30%, but few studies have attempted to correlate depression with quality of life (QOL) in these patients. The present study investigates the association between depression and QOL in people living with HTLV-1.
A clinical-epidemiological questionnaire, the Mini International Neuropsychiatric Interview and the WHOQOL-Bref were applied to 88 HTLV-1-infected patients (32 with TSP/HAM) at the HTLV Center of the Bahiana School of Medicine and Public Health, Salvador, Brazil.
The prevalence of depression among people living with HTLV-1 was 34.1%. Depression was significantly associated with a poor QOL in the physical, psychological, social relationship and environment domains, when controlling for other variables, such as gender, age, time of knowledge of serological diagnosis and presence of tropical spastic paraparesis/HTLV-1associated myelopathy (TSP/HAM). Moreover, patients with TSP/HAM experienced a reduction in their QOL in the physical, psychological and environment domains.
Our results showed that depression negatively affects the quality of life of people living with HTLV-1, regardless of the presence of TSP/HAM. Since it is possible to improve a patient's QOL by treating depression, psychological evaluations are strongly recommended as a measure to integrate the treatment protocols of HTLV-1 intervention programs.
先前的研究发现，HTLV-1 感染患者的抑郁患病率约为 30%，但很少有研究试图将抑郁与这些患者的生活质量（QOL）相关联。本研究调查了 HTLV-1 感染者中抑郁与 QOL 之间的关联。
在巴西萨尔瓦多的巴伊亚医学院和公共卫生 HTLV 中心，对 88 名 HTLV-1 感染患者（32 名 TSP/HAM）应用临床流行病学问卷、迷你国际神经精神病访谈和 WHOQOL-Bref 进行调查。
HTLV-1 感染者的抑郁患病率为 34.1%。在控制性别、年龄、血清学诊断知识时间和热带痉挛性截瘫/HTLV-1 相关脊髓病（TSP/HAM）的存在等其他变量后，抑郁与 QOL 在生理、心理、社会关系和环境领域的不良显著相关。此外，TSP/HAM 患者在生理、心理和环境领域的 QOL 均下降。
我们的结果表明，抑郁会对 HTLV-1 感染者的生活质量产生负面影响，无论是否存在 TSP/HAM。由于通过治疗抑郁可以改善患者的 QOL，因此强烈建议进行心理评估，作为整合 HTLV-1 干预计划治疗方案的措施。
