Kirkali Z, Cowan S, Leake R E
Department of Urology, Western Infirmary, Glasgow, Scotland.
Int Urol Nephrol. 1990;22(3):231-4. doi: 10.1007/BF02550398.
Androgen receptors were measured in transitional cell carcinoma tissues obtained from 13 patients with bladder tumours and 3 patients with ureteric tumours. Scatchard analysis of binding of mibolerone, a synthetic androgen, was used for receptor measurement. None of the patients were receptor positive. This study suggests that human male hormones do not play any direct role in the malignant transformation of human transitional cell epithelium.
在取自13例膀胱肿瘤患者和3例输尿管肿瘤患者的移行细胞癌组织中检测雄激素受体。使用合成雄激素米勃龙结合的Scatchard分析来测量受体。所有患者均无受体阳性。本研究表明，人类男性激素在人类移行细胞上皮的恶性转化中不发挥任何直接作用。
