Ekman P
Acta Obstet Gynecol Scand Suppl. 1981;101:87-92. doi: 10.3109/00016348109157819.
Within urological practice, three important types of cancer seem to be under endocrine influence or develop in endocrine-dependent organs: prostate cancer, hypernephroma and testicular tumors. Endocrine therapy is not used in testicular cancer, its value in renal cell carcinoma is limited, whereas it is a dominant form of therapy for prostate cancer. There seems to be a definite relation between androgen receptor content in primary prostatic carcinoma and response to hormonal manipulations. The presence of estrogen receptors is not well documented and probably the major effect of estrogen therapy is indirect, being exerted via the hypothalamo-pituitary axis. Progestin receptors are present in hyperplastic prostate as well as in prostate cancer and may indicate cases sensitive to progestin therapy. The assay method still needs considerable refinement before it can be introduced into clinical practice.
在泌尿外科领域，似乎有三种重要类型的癌症受内分泌影响或发生于内分泌依赖器官：前列腺癌、肾细胞癌和睾丸肿瘤。内分泌疗法并不用于睾丸癌，其在肾细胞癌中的价值有限，而它是前列腺癌的主要治疗方式。原发性前列腺癌中的雄激素受体含量与激素治疗反应之间似乎存在明确关联。雌激素受体的存在尚无充分记录，雌激素治疗的主要作用可能是间接的，通过下丘脑 - 垂体轴发挥作用。孕激素受体存在于增生性前列腺以及前列腺癌中，可能提示对孕激素治疗敏感的病例。在该检测方法能够引入临床实践之前，仍需要大幅改进。
