Department of Senology, University of Cologne, Cologne, Germany.
Anticancer Res. 2011 Nov;31(11):4039-42.
The objective was the investigation of a possible predictive quantitative impact of initial tumor sphericity, measured by 3D sonography, on response to pre-operative chemotherapy.
This 3D ultrasound study was conducted on 41 consecutive primary breast cancer patients who received pre-operative epirubicin and paclitaxel chemotherapy; the tumors were measured by 3D sonography and by pathology after chemotherapy. Sphericity was defined as the ratio of the smallest to the largest extent by 3D sonography.
A predictive impact of initial tumor sphericity on response to pre-operative chemotherapy was quantitatively identified for the first time. Sphericity was a significant predictor of pathological complete remission with a rank difference of 0.34 or about 1/3 i.e., spherical tumors were more likely to show successful remission.
Tumor sphericity as defined from 3D sonography could be predictive of response to pre-operative chemotherapy regimens; prospective investigation is suggested.
本研究旨在通过三维超声测量，探究肿瘤初始球形度对术前化疗反应的潜在预测作用。
本研究共纳入 41 例接受表阿霉素和紫杉醇新辅助化疗的原发性乳腺癌患者。通过三维超声和化疗后的病理检查对肿瘤进行测量。球形度定义为三维超声测量的最小径与最大径之比。
本研究首次定量确定了肿瘤初始球形度对术前化疗反应的预测作用。球形度是病理完全缓解的显著预测因子，秩差为 0.34，即球形肿瘤更有可能成功缓解。
本研究定义的肿瘤球形度可预测新辅助化疗方案的反应，建议进一步开展前瞻性研究。
