Department of Ultrasound, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
Eur Radiol. 2014 Jun;24(6):1186-96. doi: 10.1007/s00330-014-3135-8. Epub 2014 Apr 12.
To investigate the correlation of three-dimensional (3D) ultrasound features with prognostic factors in invasive ductal carcinoma.
Surgical resection specimens of 85 invasive ductal carcinomas of 85 women who had undergone 3D ultrasound were included. Morphology features and vascularization perfusion on 3D ultrasound were evaluated. Pathologic prognostic factors, including tumour size, histological grade, lymph node status, oestrogen and progesterone receptor status (ER, PR), c-erbB-2 and p53 expression, and microvessel density (MVD) were determined. Correlations of 3D ultrasound features and prognostic factors were analysed.
The retraction pattern in the coronal plane had a significant value as an independent predictor of a small tumour size (P = 0.014), a lower histological grade (P = 0.009) and positive ER or PR expression status (P = 0.001, 0.044). The retraction pattern with a hyperechoic ring only existed in low-grade and ER-positive tumours. The presence of the hyperechoic ring strengthened the ability of the retraction pattern to predict a good prognosis of breast cancer. The increased intra-tumour vascularization index (VI, the mean tumour vascularity) reflected a higher histological grade (P = 0.025) and had a positive correlation with MVD (r = 0.530, P = 0.001).
The retraction pattern and histogram indices of VI provided by 3D ultrasound may be useful in predicting prognostic information about breast cancer.
Three-dimensional ultrasound can potentially provide prognostic evaluation of breast cancer. The retraction pattern and hyperechoic ring in the coronal plane suggest good prognosis. The increased intra-tumour vascularization index reflects a higher histological grade. The intra-tumour vascularization index is positively correlated with microvessel density.
探讨三维（3D）超声特征与浸润性导管癌预后因素的相关性。
纳入 85 例接受 3D 超声检查的女性浸润性导管癌患者的 85 例手术切除标本。评估 3D 超声的形态特征和血管灌注。确定病理预后因素，包括肿瘤大小、组织学分级、淋巴结状态、雌激素和孕激素受体状态（ER、PR）、c-erbB-2 和 p53 表达以及微血管密度（MVD）。分析 3D 超声特征与预后因素的相关性。
冠状面回缩模式作为肿瘤小、组织学分级低和 ER 或 PR 表达阳性的独立预测因子（P=0.014、0.009 和 0.001、0.044）具有重要意义。仅存在高回声环的回缩模式仅存在于低分级和 ER 阳性肿瘤中。高回声环的存在增强了回缩模式预测乳腺癌良好预后的能力。肿瘤内血管化指数（VI，平均肿瘤血管密度）的增加反映了较高的组织学分级（P=0.025），并与 MVD 呈正相关（r=0.530，P=0.001）。
3D 超声提供的回缩模式和 VI 直方图指标可能有助于预测乳腺癌的预后信息。
三维超声有可能为乳腺癌提供预后评估。冠状面的回缩模式和高回声环提示预后良好。肿瘤内血管化指数增加反映组织学分级较高。肿瘤内血管化指数与微血管密度呈正相关。
