Schubert H D, Agarwala A, Arbizo V
Department of Pathology, Wills Eye Hospital, Philadelphia, Pennsylvania.
Invest Ophthalmol Vis Sci. 1990 Sep;31(9):1834-8.
To examine the possible role of transscleral outflow routes, enucleated human and porcine eyes underwent noncontact neodymium:yttrium aluminum garnet (Nd:YAG) laser cyclophotocoagulation 3 mm posterior to the limbus. Pars plana lesions were verified histologically. The eyes were perfused with saline solution at 50 mm Hg perfusion pressure, placing the tip of the needle into the hyaloid orbicular space. The outflow facility was 0.072 microliter/min/mm Hg in paired controls and 0.105 microliter/min/mm Hg in human lasered eyes, a difference of 31%. In porcine eyes the difference was 43%. Since concepts of aqueous production, impaired circulation, and inflammation do not apply to enucleated eyes, the increase may be related to pars plana transscleral flow facilitated by disruption of the neuroepithelial barrier.
为研究经巩膜流出途径的可能作用，对摘除的人眼和猪眼在角膜缘后3毫米处进行非接触钕:钇铝石榴石（Nd:YAG）激光睫状体光凝术。经组织学验证了睫状体扁平部的病变。在50毫米汞柱灌注压力下用盐溶液灌注眼睛，将针头尖端置于玻璃体环状间隙。配对对照组的流出率为0.072微升/分钟/毫米汞柱，人眼激光治疗后的流出率为0.105微升/分钟/毫米汞柱，差异为31%。在猪眼中，差异为43%。由于房水生成、循环受损和炎症的概念不适用于摘除的眼睛，这种增加可能与神经上皮屏障破坏促进的睫状体扁平部经巩膜流动有关。
