Dotis J, Stabouli S, Violaki A, Vogiatzi L, Mitroudi M, Oikonomou M, Athanassiou-Metaxa M, Kotsiou M
Hippokratia. 2011 Apr;15(2):184-6.
Transfusion-related acute lung injury (TRALI) constitutes a life threatening complication of blood transfusion. In severe TRALI cases supportive care with mechanical ventilation in intensive care unit is needed. We present two severe TRALI cases caused by leukocyte depleted, ABO compatible, packed red blood cell transfusions, coming from multiparous women donors. In the first case diagnosis was based on clinical findings and established by the identification of leukocyte antibodies in donor's unit and recipient's serum and she deal with invasive mechanical ventilation. In the second case, diagnosis was based on clinical criteria and chest radiograph findings and non-invasive mechanical ventilation was used. Both cases were treated in a Pediatric Intensive Care Unit and they had a favorable outcome.
输血相关急性肺损伤（TRALI）是一种危及生命的输血并发症。在严重的TRALI病例中，需要在重症监护病房进行机械通气的支持性治疗。我们报告了两例严重的TRALI病例，均由来自经产妇献血者的白细胞滤除、ABO血型相容的浓缩红细胞输血引起。第一例病例的诊断基于临床发现，并通过检测献血者血液和受血者血清中的白细胞抗体得以确诊，患者接受了有创机械通气治疗。第二例病例的诊断基于临床标准和胸部X光片检查结果，采用了无创机械通气治疗。两例患者均在儿科重症监护病房接受治疗，均取得了良好的治疗效果。
