Collins Michael A
Biochemistry Division of the Department of Cell Biology and Neurobiology, Loyola University Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA.
Neurotoxicology. 2004 Jan;25(1-2):117-20. doi: 10.1016/S0161-813X(03)00145-1.
Although Dr. Merton Sandler's extensive and vigorous research program over the years has been concerned mainly with classical biogenic amines, monoamine oxidase (MAO), and MAO inhibitors, he and his group contributed a significant early Parkinson's disease-related study of a non-classical or "aberrant" biogenic amine. The formation and production of this amine, the dopamine-derived mammalian alkaloid, tetrahydropapaveroline (THP), is in fact dependent on MAO activity. As reviewed here, that study provided the groundwork for and indeed stimulated many later investigations of mammalian alkaloids in numerous laboratories around the world.
尽管默顿·桑德勒博士多年来广泛而积极的研究项目主要关注经典生物胺、单胺氧化酶（MAO）和MAO抑制剂，但他和他的团队对一种非经典或“异常”生物胺进行了一项与帕金森病相关的重要早期研究。这种胺，即多巴胺衍生的哺乳动物生物碱四氢罂粟碱（THP）的形成和产生实际上依赖于MAO活性。如本文所述，该研究为世界各地众多实验室后来对哺乳动物生物碱的许多研究奠定了基础，并确实激发了这些研究。
