• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

游离脂肪酸、脂肪因子和罗格列酮对3T3-L1脂肪细胞中LYRM1基因表达的调控

Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes.

作者信息

Zhang Min, Zhao Hai-Ming, Qin Zhen-Ying, Qin Rui, Chen Xiao-Hui, Zhao Ya-Ping, Zhang Chun-Mei, Gao Chun-Lin, Zhu Chun, Ji Chen-Bo, Cao Xin-Guo, Guo Xi-Rong

机构信息

Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing 210004, China.

出版信息

Exp Diabetes Res. 2012;2012:820989. doi: 10.1155/2012/820989. Epub 2011 Oct 26.

DOI:10.1155/2012/820989
PMID:22110480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3205718/
Abstract

LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.

摘要

含LYR基序1（LYRM1）是一种新基因，在肥胖受试者的脂肪组织中大量表达，并与胰岛素抵抗有关。在本研究中，游离脂肪酸（FFA）和肿瘤坏死因子-α（TNF-α）可上调3T3-L1脂肪细胞中LYRM1 mRNA的表达。相反，抵抗素和罗格列酮对LYRM1 mRNA的表达有抑制作用。这些结果表明，LYRM1 mRNA的表达受多种与胰岛素敏感性相关的因素影响。LYRM1可能是肥胖相关胰岛素抵抗发生发展中的一个重要介质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/c327076a82f1/EDR2012-820989.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/630fd656b7dd/EDR2012-820989.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/e672bafcbac9/EDR2012-820989.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/6d8c494bf98e/EDR2012-820989.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/3951b092144e/EDR2012-820989.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/c327076a82f1/EDR2012-820989.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/630fd656b7dd/EDR2012-820989.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/e672bafcbac9/EDR2012-820989.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/6d8c494bf98e/EDR2012-820989.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/3951b092144e/EDR2012-820989.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24aa/3205718/c327076a82f1/EDR2012-820989.005.jpg

相似文献

1
Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes.游离脂肪酸、脂肪因子和罗格列酮对3T3-L1脂肪细胞中LYRM1基因表达的调控
Exp Diabetes Res. 2012;2012:820989. doi: 10.1155/2012/820989. Epub 2011 Oct 26.
2
NYGGF4 homologous gene expression in 3T3-L1 adipocytes: regulation by FFA and adipokines.3T3-L1 脂肪细胞中 NYGGF4 同源基因的表达：FFA 和脂肪因子的调节。
Mol Biol Rep. 2010 Oct;37(7):3291-6. doi: 10.1007/s11033-009-9914-7. Epub 2009 Nov 6.
3
FFAs and adipokine-mediated regulation of hsa-miR-143 expression in human adipocytes.游离脂肪酸和脂肪因子对人脂肪细胞中 hsa-miR-143 表达的调节。
Mol Biol Rep. 2013 Oct;40(10):5669-75. doi: 10.1007/s11033-013-2668-2. Epub 2013 Sep 25.
4
Knockdown of LYRM1 rescues insulin resistance and mitochondrial dysfunction induced by FCCP in 3T3-L1 adipocytes.敲低LYRM1可挽救FCCP在3T3-L1脂肪细胞中诱导的胰岛素抵抗和线粒体功能障碍。
Cell Biochem Biophys. 2014 Sep;70(1):667-75. doi: 10.1007/s12013-014-9971-y.
5
Overexpression of LYRM1 induces mitochondrial impairment in 3T3-L1 adipocytes.LYRM1 的过表达导致 3T3-L1 脂肪细胞中线粒体损伤。
Mol Genet Metab. 2010 Dec;101(4):395-9. doi: 10.1016/j.ymgme.2010.08.010. Epub 2010 Aug 19.
6
α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway.α-硫辛酸通过 IRS-1/Akt 信号通路改善 LYRM1 过表达 3T3-L1 脂肪细胞的葡萄糖摄取受损。
J Bioenerg Biomembr. 2012 Oct;44(5):579-86. doi: 10.1007/s10863-012-9460-1. Epub 2012 Jul 22.
7
Adipokines and free fatty acids regulate insulin sensitivity by increasing microRNA-21 expression in human mature adipocytes.脂肪因子和游离脂肪酸通过增加人类成熟脂肪细胞中微小RNA-21的表达来调节胰岛素敏感性。
Mol Med Rep. 2017 Aug;16(2):2254-2258. doi: 10.3892/mmr.2017.6769. Epub 2017 Jun 14.
8
Differential expression of adrenomedullin and resistin in 3T3-L1 adipocytes treated with tumor necrosis factor-alpha.肿瘤坏死因子-α处理的3T3-L1脂肪细胞中肾上腺髓质素和抵抗素的差异表达
Eur J Endocrinol. 2003 Sep;149(3):231-8. doi: 10.1530/eje.0.1490231.
9
LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes.LYRM1，一种新型基因，可促进前脂肪细胞的增殖并抑制其凋亡。
Eur J Endocrinol. 2009 Feb;160(2):177-84. doi: 10.1530/EJE-08-0518. Epub 2008 Nov 20.
10
Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells.3T3-L1和小鼠脂肪细胞中抵抗素表达的体液调节。
Diabetes. 2002 Jun;51(6):1737-44. doi: 10.2337/diabetes.51.6.1737.

引用本文的文献

1
The polymorphisms of LYRM1 gene and their association with body measurement and ultrasound traits of Qinchuan cattle.LYRM1 基因多态性及其与秦川牛体尺和超声性状的关系。
Mol Biol Rep. 2013 Feb;40(2):1511-7. doi: 10.1007/s11033-012-2195-6. Epub 2012 Nov 7.
2
α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway.α-硫辛酸通过 IRS-1/Akt 信号通路改善 LYRM1 过表达 3T3-L1 脂肪细胞的葡萄糖摄取受损。
J Bioenerg Biomembr. 2012 Oct;44(5):579-86. doi: 10.1007/s10863-012-9460-1. Epub 2012 Jul 22.

本文引用的文献

1
Inflammatory mechanisms in obesity.肥胖中的炎症机制。
Annu Rev Immunol. 2011;29:415-45. doi: 10.1146/annurev-immunol-031210-101322.
2
Over-expression of LYRM1 inhibits glucose transport in rat skeletal muscles via attenuated phosphorylation of PI3K (p85) and Akt.LYRM1 的过表达通过减弱 PI3K（p85）和 Akt 的磷酸化来抑制大鼠骨骼肌中的葡萄糖转运。
Mol Cell Biochem. 2011 Feb;348(1-2):149-54. doi: 10.1007/s11010-010-0649-5. Epub 2010 Nov 12.
3
Overexpression of LYRM1 induces mitochondrial impairment in 3T3-L1 adipocytes.LYRM1 的过表达导致 3T3-L1 脂肪细胞中线粒体损伤。
Mol Genet Metab. 2010 Dec;101(4):395-9. doi: 10.1016/j.ymgme.2010.08.010. Epub 2010 Aug 19.
4
The genetic contribution to non-syndromic human obesity.遗传因素对非综合征性人类肥胖的影响。
Nat Rev Genet. 2009 Jul;10(7):431-42. doi: 10.1038/nrg2594.
5
LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes.LYRM1，一种新型基因，可促进前脂肪细胞的增殖并抑制其凋亡。
Eur J Endocrinol. 2009 Feb;160(2):177-84. doi: 10.1530/EJE-08-0518. Epub 2008 Nov 20.
6
Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-kappaB pathway in adipocytes links nutritional signalling with innate immunity.脂肪酸诱导脂肪细胞中Toll样受体4/核因子-κB信号通路，将营养信号与天然免疫联系起来。
Immunology. 2009 Feb;126(2):233-45. doi: 10.1111/j.1365-2567.2008.02892.x. Epub 2008 Jun 23.
7
Type 2 diabetes: pathogenesis and treatment.2型糖尿病：发病机制与治疗
Lancet. 2008 Jun 28;371(9631):2153-6. doi: 10.1016/S0140-6736(08)60932-0.
8
Is the obesity epidemic exaggerated? No.肥胖流行被夸大了吗？没有。
BMJ. 2008 Feb 2;336(7638):245. doi: 10.1136/bmj.39458.495127.AD.
9
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance.脂肪组织功能障碍在肥胖相关胰岛素抵抗发病机制中的作用。
Physiol Behav. 2008 May 23;94(2):206-18. doi: 10.1016/j.physbeh.2007.10.010. Epub 2007 Oct 22.
10
Role of FoxO1 in FFA-induced oxidative stress in adipocytes.FoxO1在游离脂肪酸诱导的脂肪细胞氧化应激中的作用。
Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E159-64. doi: 10.1152/ajpendo.00629.2006. Epub 2007 Mar 20.