Walley Andrew J, Asher Julian E, Froguel Philippe
Section of Genomic Medicine, Imperial College London, Burlington-Danes Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Nat Rev Genet. 2009 Jul;10(7):431-42. doi: 10.1038/nrg2594.
The last few years have seen major advances in common non-syndromic obesity research, much of it the result of genetic studies. This Review outlines the competing hypotheses about the mechanisms underlying the genetic and physiological basis of obesity, and then examines the recent explosion of genetic association studies that have yielded insights into obesity, both at the candidate gene level and the genome-wide level. With obesity genetics now entering the post-genome-wide association scan era, the obvious question is how to improve the results obtained so far using single nucleotide polymorphism markers and how to move successfully into the other areas of genomic variation that may be associated with common obesity.
在过去几年中，常见的非综合征性肥胖研究取得了重大进展，其中大部分是基因研究的成果。本综述概述了关于肥胖的遗传和生理基础机制的相互竞争的假说，然后审视了近期基因关联研究的爆发，这些研究在候选基因水平和全基因组水平上都为肥胖研究带来了新见解。随着肥胖遗传学进入全基因组关联扫描后的时代，一个明显的问题是如何改进目前使用单核苷酸多态性标记所获得的结果，以及如何成功进入可能与常见肥胖相关的其他基因组变异领域。
