凤凰木（Boj. Ex. Hook.）的抗炎活性
Anti-Inflammatory Activity of Delonix regia (Boj. Ex. Hook).
作者信息
Shewale Vaishali D, Deshmukh Tushar A, Patil Liladhar S, Patil Vijay R
机构信息
Tapi Valley Education Society, Hon'ble, Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur 425 503, India.
出版信息
Adv Pharmacol Sci. 2012;2012:789713. doi: 10.1155/2012/789713. Epub 2011 Nov 1.
Abstract
The present work was to evaluate the anti-inflammatory activity of Delonix regia leaves (Family: Caesalpiniaceae). The powder of Delonix regia leaves was subjected to extraction with ethanol in soxhlet extractor. The ethanol extract after preliminary phytochemical investigation showed the presence of sterols, triterpenoids, phenolic compounds and flavonoids. The anti-inflammatory activity was studied using carrageenan-induced rat paw edema and cotton pellet granuloma at a three different doses (100, 200, and 400 mg/kg b.w. p.o.) of ethanol extract. The ethanol extract of Delonix regia leaves was exhibited significant anti-inflammatory activity at the dose of 400 mg/kg in both models when compared with control group. Indomethacin (10 mg/kg b.w. p.o) was also shown significant anti-inflammatory activity in both models.
摘要
本研究旨在评估凤凰木叶子（豆科）的抗炎活性。凤凰木叶子粉末在索氏提取器中用乙醇进行提取。初步植物化学研究后的乙醇提取物显示含有甾醇、三萜类化合物、酚类化合物和黄酮类化合物。使用角叉菜胶诱导的大鼠足爪肿胀和棉球肉芽肿模型，以三种不同剂量（100、200和400毫克/千克体重，口服）的乙醇提取物研究其抗炎活性。与对照组相比，凤凰木叶子的乙醇提取物在两种模型中均在400毫克/千克剂量时表现出显著的抗炎活性。吲哚美辛（10毫克/千克体重，口服）在两种模型中也显示出显著的抗炎活性。
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