维甲酸对角蛋白表达的调控。
Regulation of keratin expression by retinoids.
作者信息
Törmä Hans
机构信息
Department of Medical Sciences/Dermatology; Uppsala University; Uppsala, Sweden.
出版信息
Dermatoendocrinol. 2011 Jul;3(3):136-40. doi: 10.4161/derm.3.3.15026. Epub 2011 Jul 1.
Abstract
Vitamin A and its natural and synthetic metabolites (retinoids) affect growth and differentiation of human skin and among the genes affected by retinoids in epidermis are keratin genes. Keratins are intermediate filament proteins that have essential functions in maintaining the structural integrity of epidermis and its appendages. Their expressions are under strict control to produce keratins that are optimally adapted to their environment. In this article, retinoid regulation of keratin expression in cultured human epidermal keratinocytes and in human skin in vivo will be reviewed. The direct and indirect mechanisms involved will be discussed and novel therapeutic strategies will be proposed for utilizing retinoids in skin disorders due to keratin mutations (e.g., epidermolysis bullosa simplex and epidermolytic ichthyosis).
摘要
维生素A及其天然和合成代谢产物（类视黄醇）会影响人类皮肤的生长和分化，而表皮中受类视黄醇影响的基因包括角蛋白基因。角蛋白是中间丝蛋白，在维持表皮及其附属器的结构完整性方面具有重要功能。它们的表达受到严格控制，以产生最适合其环境的角蛋白。在本文中，将综述类视黄醇对培养的人表皮角质形成细胞和体内人皮肤中角蛋白表达的调节作用。将讨论其中涉及的直接和间接机制，并针对因角蛋白突变引起的皮肤疾病（如单纯性大疱性表皮松解症和表皮松解性鱼鳞病）利用类视黄醇提出新的治疗策略。
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