• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Regulation of keratin expression by retinoids.维甲酸对角蛋白表达的调控。
Dermatoendocrinol. 2011 Jul;3(3):136-40. doi: 10.4161/derm.3.3.15026. Epub 2011 Jul 1.
2
Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARalpha.角蛋白 2 和 4/13 在重建的人体皮肤中受核受体 RARalpha 结合的视黄酸调节呈反向调控。
Exp Dermatol. 2010 Jul 1;19(7):674-81. doi: 10.1111/j.1600-0625.2010.01079.x. Epub 2010 Apr 20.
3
Keratin gene mutations in disorders of human skin and its appendages.人类皮肤及其附属物疾病中的角蛋白基因突变。
Arch Biochem Biophys. 2011 Apr 15;508(2):123-37. doi: 10.1016/j.abb.2010.12.019. Epub 2010 Dec 19.
4
Human keratin diseases: hereditary fragility of specific epithelial tissues.人类角蛋白疾病：特定上皮组织的遗传性脆性
Exp Dermatol. 1996 Dec;5(6):297-307. doi: 10.1111/j.1600-0625.1996.tb00133.x.
5
Retinoids reduce formation of keratin aggregates in heat-stressed immortalized keratinocytes from an epidermolytic ichthyosis patient with a KRT10 mutation*.类视黄醇可减少热应激突变型表皮松解性鱼鳞病患者永生化角质形成细胞中角蛋白聚集的形成*。
Acta Derm Venereol. 2013 Jan;93(1):44-9. doi: 10.2340/00015555-1368.
6
Disease severity correlates with position of keratin point mutations in patients with epidermolysis bullosa simplex.单纯性大疱性表皮松解症患者的疾病严重程度与角蛋白点突变的位置相关。
Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3197-201. doi: 10.1073/pnas.90.8.3197.
7
The molecular basis for inherited bullous diseases.遗传性大疱性疾病的分子基础。
J Mol Med (Berl). 1996 Feb;74(2):59-70. doi: 10.1007/BF00196781.
8
The molecular genetics of keratin disorders.角蛋白紊乱的分子遗传学
Am J Clin Dermatol. 2003;4(5):347-64. doi: 10.2165/00128071-200304050-00005.
9
Genetic bases of epidermolysis bullosa simplex and epidermolytic hyperkeratosis.单纯性大疱性表皮松解症和表皮松解性角化过度症的遗传基础。
J Invest Dermatol. 1994 Nov;103(5 Suppl):25S-30S. doi: 10.1111/1523-1747.ep12398924.
10
Mutations in the genes for epidermal keratins in epidermolysis bullosa and epidermolytic hyperkeratosis.大疱性表皮松解症和表皮松解性角化过度症中表皮角蛋白基因的突变。
Arch Dermatol. 1993 Dec;129(12):1571-7.

引用本文的文献

1
How Cells Die in Psoriasis?银屑病中细胞是如何死亡的？
Int J Mol Sci. 2025 Apr 16;26(8):3747. doi: 10.3390/ijms26083747.
2
Toxicity and efficacy study of a combination of two retinoic acids in an ApoE knockout mouse model of atherosclerosis.两种视黄酸联合应用于载脂蛋白E基因敲除小鼠动脉粥样硬化模型的毒性和疗效研究。
Korean J Physiol Pharmacol. 2025 Mar 1;29(2):179-189. doi: 10.4196/kjpp.24.165. Epub 2024 Nov 14.
3
Disseminated superficial actinic porokeratosis treated with tretinoin and calcipotriene.外用维甲酸和骨化三醇治疗播散性浅表性光化性汗孔角化症。
JAAD Case Rep. 2024 Sep 20;53:105-108. doi: 10.1016/j.jdcr.2024.08.040. eCollection 2024 Nov.
4
Vitamin A Metabolism and Resistance of Hepatic Metastases to Immunotherapy.维生素A代谢与肝转移瘤对免疫治疗的耐药性
Mol Cancer Ther. 2025 Mar 4;24(3):345-353. doi: 10.1158/1535-7163.MCT-24-0367.
5
Keratin 8/18a.1 Expression Influences Embryonic Neural Crest Cell Dynamics and Contributes to Postnatal Corneal Regeneration in Zebrafish.角蛋白 8/18a.1 表达影响胚胎神经嵴细胞动力学，并有助于斑马鱼的出生后角膜再生。
Cells. 2024 Sep 2;13(17):1473. doi: 10.3390/cells13171473.
6
Identifying Molecular Pathophysiology and Potential Therapeutic Options in Iatrogenic Tracheal Stenosis.识别医源性气管狭窄的分子病理生理学及潜在治疗方案
Biomedicines. 2024 Jun 14;12(6):1323. doi: 10.3390/biomedicines12061323.
7
The retinoid X receptor has a critical role in synthetic rexinoid-induced increase in cellular all-trans-retinoic acid.视黄醇 X 受体在合成维甲酸诱导的细胞全反式维甲酸增加中起关键作用。
PLoS One. 2024 Apr 1;19(4):e0301447. doi: 10.1371/journal.pone.0301447. eCollection 2024.
8
imaging of patients with chronic pruritus of unknown origin reveals partial sweat duct obstruction with partial itch resolution upon retinoid treatment.对不明原因慢性瘙痒患者的影像学检查显示存在部分汗腺导管阻塞，使用维甲酸治疗后瘙痒部分缓解。
Front Med (Lausanne). 2023 Sep 22;10:1265148. doi: 10.3389/fmed.2023.1265148. eCollection 2023.
9
One-year longitudinal study of the stratum corneum proteome of retinol and all-trans-retinoic acid treated human skin: an orchestrated molecular event.视黄醇和全反式维 A 酸处理人皮肤角质层蛋白质组的一年纵向研究：一个协调的分子事件。
Sci Rep. 2023 Jul 11;13(1):11196. doi: 10.1038/s41598-023-37750-5.
10
In a Preliminary Study on Human Subjects, a Cosmetic Cream Containing a Plant Extract Induces Similar Anti-Aging Effects to a Retinol-Containing Cream.在一项针对人体受试者的初步研究中，一种含有植物提取物的面霜与含视黄醇的面霜具有相似的抗老化效果。
Clin Cosmet Investig Dermatol. 2023 Apr 19;16:1051-1058. doi: 10.2147/CCID.S401290. eCollection 2023.

本文引用的文献

1
Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: a useful in vitro model for testing new treatments.从表皮松解性鱼鳞病患者中分离的永生化角质形成细胞再现疾病表型：一种用于测试新疗法的有用的体外模型。
Br J Dermatol. 2011 Feb;164(2):263-72. doi: 10.1111/j.1365-2133.2010.10092.x.
2
Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia.萝卜硫素通过 Nrf2 依赖和非依赖途径对皮肤上皮细胞角蛋白表达的差异调节。
Mol Biol Cell. 2010 Dec;21(23):4068-75. doi: 10.1091/mbc.E10-02-0153. Epub 2010 Oct 6.
3
Keratins 2 and 4/13 in reconstituted human skin are reciprocally regulated by retinoids binding to nuclear receptor RARalpha.角蛋白 2 和 4/13 在重建的人体皮肤中受核受体 RARalpha 结合的视黄酸调节呈反向调控。
Exp Dermatol. 2010 Jul 1;19(7):674-81. doi: 10.1111/j.1600-0625.2010.01079.x. Epub 2010 Apr 20.
4
Cytokeratins 16 and 10 bind to retinoic acid covalently in skin tissue of mice.细胞角蛋白 16 和 10 与维甲酸在小鼠皮肤组织中发生共价结合。
Br J Dermatol. 2010 May;162(5):974-9. doi: 10.1111/j.1365-2133.2009.09592.x. Epub 2009 Nov 18.
5
Comprehensive transcriptional profiling of human epidermis, reconstituted epidermal equivalents, and cultured keratinocytes using DNA microarray chips.使用DNA微阵列芯片对人表皮、重组表皮替代物和培养的角质形成细胞进行全面转录谱分析。
Methods Mol Biol. 2010;585:193-223. doi: 10.1007/978-1-60761-380-0_15.
6
Actin-dependent dynamics of keratin filament precursors.角蛋白丝前体的肌动蛋白依赖性动力学
Cell Motil Cytoskeleton. 2009 Nov;66(11):976-85. doi: 10.1002/cm.20395.
7
Retinoid-responsive transcriptional changes in epidermal keratinocytes.表皮角质形成细胞中类视黄醇反应性转录变化。
J Cell Physiol. 2009 Aug;220(2):427-439. doi: 10.1002/jcp.21784.
8
Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis.全反式维甲酸和细胞色素P450（CYP26）抑制剂均会影响器官型表皮中维生素A代谢酶和类视黄醇生物标志物的表达。
Arch Dermatol Res. 2009 Aug;301(7):475-85. doi: 10.1007/s00403-009-0937-7. Epub 2009 Mar 18.
9
The unfolded protein response is activated in differentiating epidermal keratinocytes.未折叠蛋白反应在分化的表皮角质形成细胞中被激活。
J Invest Dermatol. 2009 Sep;129(9):2126-35. doi: 10.1038/jid.2009.51. Epub 2009 Mar 12.
10
The molecular basis of human keratin disorders.人类角蛋白疾病的分子基础。
Hum Genet. 2009 May;125(4):355-73. doi: 10.1007/s00439-009-0646-5. Epub 2009 Feb 27.

维甲酸对角蛋白表达的调控。

Regulation of keratin expression by retinoids.

作者信息

Törmä Hans

机构信息

Department of Medical Sciences/Dermatology; Uppsala University; Uppsala, Sweden.

出版信息

Dermatoendocrinol. 2011 Jul;3(3):136-40. doi: 10.4161/derm.3.3.15026. Epub 2011 Jul 1.

DOI:10.4161/derm.3.3.15026
PMID:22110773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3219164/
Abstract

Vitamin A and its natural and synthetic metabolites (retinoids) affect growth and differentiation of human skin and among the genes affected by retinoids in epidermis are keratin genes. Keratins are intermediate filament proteins that have essential functions in maintaining the structural integrity of epidermis and its appendages. Their expressions are under strict control to produce keratins that are optimally adapted to their environment. In this article, retinoid regulation of keratin expression in cultured human epidermal keratinocytes and in human skin in vivo will be reviewed. The direct and indirect mechanisms involved will be discussed and novel therapeutic strategies will be proposed for utilizing retinoids in skin disorders due to keratin mutations (e.g., epidermolysis bullosa simplex and epidermolytic ichthyosis).

摘要

维生素A及其天然和合成代谢产物（类视黄醇）会影响人类皮肤的生长和分化，而表皮中受类视黄醇影响的基因包括角蛋白基因。角蛋白是中间丝蛋白，在维持表皮及其附属器的结构完整性方面具有重要功能。它们的表达受到严格控制，以产生最适合其环境的角蛋白。在本文中，将综述类视黄醇对培养的人表皮角质形成细胞和体内人皮肤中角蛋白表达的调节作用。将讨论其中涉及的直接和间接机制，并针对因角蛋白突变引起的皮肤疾病（如单纯性大疱性表皮松解症和表皮松解性鱼鳞病）利用类视黄醇提出新的治疗策略。