López Tessy, Islas Emma Ortíz, Alvarez Lemus Mayra A, González Richard Donald
Health Department, Universidad Autónoma Metropolitana-Xochimilco, México City, México.
Nano Rev. 2011;2. doi: 10.3402/nano.v2i0.5461. Epub 2011 Jan 13.
In vivo suppression of glioblastoma multiforme (GBM) in Wistar rats using silica-shelled biocatalytic Pt(NH(3))(4)Cl(2) nanoparticles is reported. These nanoparticles were synthesized by a sol-gel technique and characterized by SEM and HRTEM imaging. We confirmed morphological uniformity (30 nm) and surface acidity of the nanoparticles, respectively, by TEM imaging and FTIR spectral analysis. Interestingly, treatment of Wistar rats intraperitoneally inoculated with C(6) cells using the biocatalysts resulted in considerable tumor shrinkage. Efficiency of the biocatalyst to shrink a tumor is superior to that by the commercial cytotoxic agent cisplatin. The tumor suppression property of Pt(NH(3))(4)Cl(2) nanoparticles is attributed to catalytic damage of DNA in C(6) cells.
据报道，使用二氧化硅壳生物催化的Pt(NH₃)₄Cl₂纳米颗粒在Wistar大鼠体内对多形性胶质母细胞瘤（GBM）有抑制作用。这些纳米颗粒通过溶胶-凝胶技术合成，并通过扫描电子显微镜（SEM）和高分辨率透射电子显微镜（HRTEM）成像进行表征。我们分别通过透射电子显微镜成像和傅里叶变换红外光谱（FTIR）分析证实了纳米颗粒的形态均匀性（30纳米）和表面酸度。有趣的是，使用生物催化剂对腹腔接种C₆细胞的Wistar大鼠进行治疗，导致肿瘤显著缩小。该生物催化剂使肿瘤缩小的效率优于商业细胞毒性药物顺铂。Pt(NH₃)₄Cl₂纳米颗粒的肿瘤抑制特性归因于对C₆细胞中DNA的催化损伤。
