Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Calz. Del Hueso 1100, Col. Villa Quietud, Coyoacan 04960, D.F., Mexico.
Eur J Med Chem. 2010 May;45(5):1982-90. doi: 10.1016/j.ejmech.2010.01.043. Epub 2010 Jan 28.
Novel nanostructured TiO2 and SiO2 based biocatalysts, with 3-4 wt. % of Pt have been developed. The obtained materials exhibit a high surface area together with a broad pore size distribution. The method of synthesis allowed obtaining high dispersed platinum metal nanoparticles. In vitro DNA reactivity test of the biocatalysts were carried out by electrophoresis and formation of DNA adducts was observed. The most active biocatalyst was H2PtCl6/SiO2. These biocatalysts were also tested in an experimental model of C6 brain tumours in Wistar rats. Administration of the material was made by stereotactic brain surgery to place it directly in the malignant tissue. A significant decrease in tumour size and weight as well as morphologic changes in cancer cells were observed.
新型纳米结构 TiO2 和 SiO2 基生物催化剂，含 3-4wt%的 Pt 已被开发出来。所得到的材料具有高的比表面积和宽的孔径分布。该合成方法允许获得高分散的铂金属纳米粒子。通过电泳进行了生物催化剂的体外 DNA 反应性测试，并观察到 DNA 加合物的形成。最活跃的生物催化剂是 H2PtCl6/SiO2。这些生物催化剂也在 Wistar 大鼠 C6 脑肿瘤的实验模型中进行了测试。通过立体定向脑外科手术将材料给药，直接放置在恶性组织中。观察到肿瘤体积和重量的显著减少以及癌细胞的形态变化。
